ID 112922
Title Alternative
Cepharanthine Inhibits IFN-γ-Induced CXCL10
Author
Keywords
cepharanthine
CXCL10
IFN-γ
JAK/STAT1 signaling
salivary gland ductal cells
primary Sjögren’s syndrome
Content Type
Journal Article
Description
Cepharanthine, a biscolaurine alkaloid isolated from the plant Stephania cephalantha Hayata, has been reported to have potent anti-inflammatory properties. Here we investigated the effects of cepharanthine on the expression of CXCL10 (a CXC chemokine induced by interferon-gamma [IFN-γ] that has been observed in a wide variety of chronic inflammatory disorders and autoimmune conditions) in IFN-γ-treated human salivary gland cell lines. We observed that IFN-γ induced CXCL10 production in NS-SV-DC cells (a human salivary gland ductal cell line), but not in NS-SV-AC cells (a human salivary gland acinar cell line). Cepharanthine inhibited the IFN-γ-induced CXCL10 production in NS-SV-DC cells. A Western blot analysis showed that cepharanthine prevented the phosphorylation of JAK2 and STAT1, but did not interfere with the NF-κB pathway. Moreover, cepharanthine inhibited the IFN-γ-mediated chemotaxis of Jurkat T cells. These results suggest that cepharanthine suppresses IFN-γ-induced CXCL10 production via the inhibition of the JAK2/STAT1 signaling pathway in human salivary gland ductal cells. Our findings also indicate that cepharanthine could inhibit the chemotaxis of Jurkat T cells by reducing CXCL10 production.
Journal Title
Inflammation
ISSN
03603997
15732576
NCID
AA00673765
AA12117940
Publisher
Springer
Volume
41
Issue
1
Start Page
50
End Page
58
Published Date
2017-09-06
Remark
This is a post-peer-review, pre-copyedit version of an article published in Inflammation. The final authenticated version is available online at: https://doi.org/10.1007/s10753-017-0662-x
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
University Hospital
Oral Sciences