ID | 112926 |
Title Alternative | 健常日本人小児における脈絡膜厚の経時的変化 : 縦断研究
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Author |
Ohsugi, Eiko
Tokushima University|Saneikai Tsukazaki Hospital
Mitamura, Yoshinori
Tokushima University
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Shinomiya, Kayo
Tokushima University
Tokushima University Educator and Researcher Directory
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Sano, Hiroki
Tokushima University
Nagasawa, Toshihiko
Saneikai Tsukazaki Hospital|Tokushima University
Shimizu, Yukiko
Saneikai Tsukazaki Hospital
Nagasato, Daisuke
Saneikai Tsukazaki Hospital|Tokushima University
Tabuchi, Hitoshi
Saneikai Tsukazaki Hospital|Tokushima University
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Keywords | choroidal thickness
longitudinal study
pediatrics
swept-source optical coherence tomography
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Content Type |
Thesis or Dissertation
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Description | AIM: To investigate the changes in the choroidal thickness in healthy pediatric children in a longitudinal study, and to determine the ocular and systemic parameters that were significantly correlated with the changes in the choroidal thickness.
METHODS: This study included 64 eyes of 34 healthy Japanese children with a mean age (±SD) of 4.4 (±0.4)y (range, 3.6-5.8y) at baseline. Swept-source optical coherence tomography (SS-OCT) was used to record images of the retina and choroid at the baseline and after a mean follow-up period of about 1.5y. The 3D raster scan protocol was used to construct the choroidal thickness map. Mean choroidal thickness was calculated for each of the nine sectors of the Early Treatment Diabetic Retinopathy Study grid. Best-corrected visual acuity, axial length, body height, and weight were also measured. Changes in measurements were defined as the baseline values subtracted from the values at the final visit. A generalized estimating equation was used to eliminate the effect of within-subject intereye correlations. RESULTS: The mean central choroidal thickness was significantly reduced during the follow-up period (baseline, 301.8±8.6 μm; final visit, 286.6±8.0 μm, P<0.001). The decrease in the choroidal thickness was greatest in the central sector, followed by the sectors of the inner and outer rings. The inner and outer rings had diameters of 1 to 3 mm and 3 to 6 mm, respectively. The changes in the choroidal thickness in the central, inner ring, and outer ring sectors were significantly and negatively correlated with the age, baseline body height, baseline body weight, and elongation of the axial length. CONCLUSION: These results indicate that the choroidal thickness among preschool-aged Japanese children decreased significantly during the follow-up period. The choroidal thinning is significantly associated with the elongation of axial length. These characteristics should be considered in the evaluation of choroidal thickness in younger children with retinochoroidal disorders. |
Journal Title |
International Journal of Ophthalmology
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ISSN | 22223959
22274898
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Publisher | IJO Press Co., Limited
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Volume | 11
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Issue | 7
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Start Page | 1179
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End Page | 1184
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Published Date | 2018-07-18
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Remark | 内容要旨・審査要旨・論文本文の公開
本論文は, 著者Eiko Ohsugiの学位論文として提出され, 学位審査・授与の対象となっている。 |
Rights | © 2018. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
ETD
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MEXT report number | 甲第3244号
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Diploma Number | 甲医第1393号
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Granted Date | 2018-11-22
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Degree Name |
Doctor of Medical Science
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Grantor |
Tokushima University
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departments |
Medical Sciences
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