Matsuzaki, Toshiya Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Tungalagsuvd, Altankhuu Tokushima University
Iwasa, Takeshi Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Munkhzaya, Munkhsaikhan Tokushima University
Yano, Kiyohito Tokushima University
Mayila, Yiliyasi Tokushima University
Tokui, Takako Tokushima University
Yanagihara, Rie Tokushima University
Kato, Takeshi Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kuwahara, Akira Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
polycystic ovary syndrome
Aim: Polycystic ovary syndrome (PCOS) is an ovulatory disorder and insulin resistance and diabetes are involved in its pathophysiology. Metformin, an anti‐diabetic agent, has been reported to be useful to induce ovulation.
Methods: Metformin treatment was classified into four types: (1) clomiphene–metformin combination treatment for clomiphene‐resistant patients; (2) clomiphene–metformin combination for clomiphene‐sensitive patients; (3) clomiphene–metformin combination for naïve patients; and (4) metformin monotherapy. The patients underwent physical, endocrinological, and clinical examinations for their ovulation rates, pregnancy rates, and follicular development.
Results: The ovulation rates, pregnancy rates, and single follicular development were not significantly different among the clomiphene–metformin combination treatment groups. In the Body Mass Index (BMI) subanalysis, the pregnancy rate was higher in the BMI≥30 kg/m2 group than in the other three groups with a BMI of ≤30 kg/m2 in both cycles and cases. The ovulation rates and pregnancy rates were significantly higher in the group with a fasting insulin of ≥15 μU/mL than in the groups with a fasting insulin of <15 μU/mL in both cycles and cases.
Conclusion: Clomiphene–metformin combination treatment appears to be useful, at least for clomiphene‐resistant patients, and a BMI of >30 kg/m2 and a fasting insulin of ≥15 μU/mL appear to be predictors of a good result with this treatment.
Reproductive Medicine and Biology
Japan Society for Reproductive Medicine|John Wiley & Sons Australia, Ltd
© 2017 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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