ID 112979
Title Alternative
Production of lipid metabolites in the intestine for the regulation of allergic diseases
脂質代謝物の産生とアレルギー疾患の制御
Author
Saika, Azusa National Institutes of Biomedical Innovation, Health and Nutrition(NIBIOHN)|Osaka University
Kunisawa, Jun National Institutes of Biomedical Innovation, Health and Nutrition(NIBIOHN)|Osaka University|The University of Tokyo|Kobe University
Keywords
Allergy
intestinal immunity
lipid metabolites
inflammation
dietary oil
Content Type
Journal Article
Description
The intestinal tract is the largest immunological organ, which is responsible for the first line of defense by preventing the invasion of pathogenic microorganism and neutralizing pathogenic materials such as toxin. Simultaneously, it does not respond to harmless or beneficial antigens such as foods and intestinal commensal bacteria. These harmonized immune responses are critical for the maintenance of intestinal homeostasis and hence disruption of the system would lead to the development of immune diseases such as inflammatory bowel disease and food allergy. Especially dietary lipids among the dietary components have been studied for a long time, and it is considered that dietary lipids are important factors for regulating the development of allergy and inflammation. As analytical techniques of lipid metabolites have been highly developed in recent years, it has become clear that some lipid metabolites derived from dietary oils have strong physiological functions including the control of allergic and inflammatory diseases. These findings are currently leading to the new methods for preventing and treating allergic and inflammatory diseases by using lipid metabolites. In this article, we introduce the control of allergic and inflammatory diseases by dietary lipids and its metabolites.
Journal Title
Shikoku Acta Medica
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
74
Issue
5-6
Start Page
137
End Page
146
Sort Key
137
Published Date
2018-12-25
FullText File
language
jpn
TextVersion
Publisher