ID 113012
Author
Maruhashi, Tomoko Tokushima University
Sumitani, Ryohei Tokushima University
Uemura, Munenori Tokushima University
Iwasa, Masami Tokushima University
Hiraga, Takashi National Health Insurance Katsuura Hospital
Kondo, Noriyasu National Health Insurance Katsuura Hospital
Fujita, Hiromi Mahara Institute of Medical Acarology
Mahara, Fumihiko Mahara Hospital
Keywords
Severe fever with thrombocytopenia syndrome
Encephalopathy
Steroid pulse therapy
Content Type
Journal Article
Description
Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne infectious disease caused by the SFTS virus (SFTSV). Clinical symptoms of SFTS often involve encephalopathy and other central neurological symptoms, particularly in seriously ill patients; however, pathogenesis of encephalopathy by SFTSV is largely unknown. Herein, we present case reports of three patients with SFTS, complicated by encephalopathy, admitted to Tokushima University hospital: one patient was a 63-year-old man, while the other two were 83- and 86-year-old women. All of them developed disturbance of consciousness around the 7th day post onset of fever. After methylprednisolone pulse therapy of 500 mg/day, all of them recovered without any neurological sequelae. SFTSV genome was not detected in the cerebrospinal fluid of 2 out of the 3 patients that were available for examination. In these patients, disturbance of consciousness seemed to be an indirect effect of the cytokine storm triggered by SFTSV infection.We propose that short-term glucocorticoid therapy might be beneficial in the treatment of encephalopathy during early phase of SFTSV infection.
Journal Title
Journal of Infection and Chemotherapy
ISSN
1341321X
NCID
AA11057978
AA11627318
Publisher
Elsevier|The Japanese Society of Chemotherapy|The Japanese Association for Infectious Disease
Volume
24
Issue
5
Start Page
389
End Page
392
Published Date
2018-02-07
Rights
© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Author
departments
Medical Sciences
University Hospital