ID 113015
Title Alternative
Pathogenesis of Cancer-associated Bone Pain
Author
Keywords
骨痛
V-ATPase
ASIC3
TRPV1
Content Type
Journal Article
Description
Bone pain is a most common and devastating complication associated with bone diseases such as osteoporosis, bone metastasis and rheumatoid arthritis. Thus, control of bone pain is a major goal in the management of these bone diseases. In bone destructive cancer, opioids are first-line therapy but palliative, unsatisfactory and inadequate. Inhibitors of osteoclasts including bisphosphonates and denosumab incompletely reduce bone pain, indicating that not only osteoclast-dependent but also osteoclast-independent mechanisms are operant. In this review, we introduce the recent study including ours, targeting the cancer cell and osteoclast created-acidic extracellular microenvironment for Cancer-associated Bone Pain (CABP).
Journal Title
Journal of Oral Health and Biosciences
ISSN
21896682
Publisher
四国歯学会
Volume
31
Issue
2
Start Page
92
End Page
96
Sort Key
92
Published Date
2019-02-06
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
jpn
TextVersion
Publisher
departments
Oral Sciences