ID 113024
Author
Nogita, Toshitatsu Shinjuku Minamiguchi Hifuka
Kimura, Ikuko Tsubasa Clinic
Chiba, Mami Iderea Skin Clinic Daikanyama
Sakakibara, Kanako Iderea Skin Clinic Daikanyama
Keywords
Alopecia areata
Glycyrrhizinate-glycine/DL-methionine combination tablets
Carpronium chloride
Allergic factors
IgE
Content Type
Journal Article
Description
Objective: Although monoammonium glycyrrhizinate/glycine/DL-methionine (MG) combination tablets have been widely used widely for the treatment of alopecia areata (AA), there are few studies on efficacious combinations with MG. This study was conducted to determine the efficacy and safety of MG plus 5% carpronium chloride (CC).
Methods: In the present interventional study, MG tablets plus 5% carpronium chloride (CC) were compared with CC monotherapy in 31 patients with AA.
Results: There were no significant differences in efficacy between the two groups, and the AA area at 8 and 12 weeks was significantly reduced in both. The results of subanalysis stratified by the presence of allergic factors as determined by IgE level showed that there were also significant decreases in the areas of AA 8 and 12 weeks after the start of the combination therapy in patients with allergic factors (p<0.05). No serious adverse events were observed in either group.
Conclusion: It is suggested that combination therapy with MG and CC has better therapeutic effects than CC monotherapy, with a significant decrease in the area of AA from 4 weeks of treatment even in mild AA patients with allergic factors.
Journal Title
Journal of Clinical & Experimental Dermatology Research
ISSN
21559554
Publisher
OMICS International
Volume
7
Issue
1
Start Page
322
Published Date
2016-01-12
Rights
Copyright: © 2015 Kubo Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences