ID 113067
Title Alternative
Prion protein in influenza A virus infection.
Author
Keywords
influenza A virus
prion protein
reactive oxygen species
Content Type
Journal Article
Description
The cellular prion protein, termed PrPC, is a glycoprotein abundantly expressed in brains and to a lesser extent in non-neuronal tissues including lungs. It was reported that PrPC is expressed by lung epithelial cells in mice, and that it may play a protective role against lethal infection with influenza A viruses (IAVs). This may occur by regulating Cu content and superoxide dismutase activity, eventually reducing oxidative stress in infected lungs. Anti-oxidative therapeutics have been demonstrated to protect mice from lethal infection with IAVs. Therefore, PrPC might be a new target molecule for development of IAV therapeutics. Here, we introduce the anti-viral mechanism of PrPC against IAV infection and discuss perspectives of PrPC-targeting therapeutics against IAV infection.
Journal Title
Future Virology
ISSN
17460794
17460808
NCID
AA12157333
Publisher
Future Medicine Ltd
Volume
14
Issue
1
Start Page
31
End Page
37
Published Date
2018-12-18
Remark
This is the Authors' final version of the following article: Cellular prion protein-mediated protection against influenza A virus infection, Junji Chida and Suehiro Sakaguchi, Future Virology 2019 14:1, 31-37, which has been published in final form at https://doi.org/10.2217/fvl-2018-0146. For full bibliographic citation, please refer to the version available at www.futuremedicine.com.
論文本文は2019-12-18以降公開予定
DOI (Published Version)
URL ( Publisher's Version )
language
eng
TextVersion
その他
departments
Institute of Advanced Medical Sciences