ID 113070
Author
Content Type
Journal Article
Description
A variety of biological redox reactions are mediated by flavoenzymes due to the unique redox activity of isoalloxazine ring systems, which are found in flavin cofactors. In the field of synthetic organic chemistry, the term “flavin” is generally used for not only isoalloxazines but also related molecules including their isomers and some analogues, and those having catalytic activity are called flavin catalyst. Flavin catalysts are typically metal-free, and their catalytic activity can be readily accessed using mild terminal oxidants such as H2O2 and O2; therefore, redox reactions with these compounds have great promise as alternatives to reactions with conventional metal catalysts for the sustainable production of important chemicals. We recently became interested in using polymers for the development of flavin catalysts, especially to improve their practicality and advance the field of catalysis. Here, we summarize our recent research on such flavin-polymer collaborations including the development of facile preparation methods for flavin catalysts using polymers, readily reusable polymer-supported flavin catalysts, and flavin-peptide-polymer hybrids that can catalyze the first flavoenzyme-mimetic aerobic oxygenation reactions.
Journal Title
Polymer Journal
ISSN
00323896
13490540
NCID
AA00777013
Publisher
The Society of Polymer Science, Japan|Springer Nature
Volume
50
Start Page
941
End Page
949
Published Date
2018-07-10
Remark
This is the Author's Accepted Manuscript of the following article: Advanced flavin catalysts elaborated with polymers, Yukihiro Arakawa, Keiji Minagawa & Yasushi Imada, Polymer Journal 50, 941-949 (2018), which has been published in final form at https://doi.org/10.1038/s41428-018-0089-8.
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DOI (Published Version)
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language
eng
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departments
Science and Technology
Liberal Arts and Sciences