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ID 113220
Title Alternative
Statins Reduce DHA in ACS
Author
Kondo, Daisuke Tokushima University
Kawabata, Yutaka Tokushima University
Saijo, Yoshihito Tokushima University
Seno, Hiromitsu Tokushima University
Sutou, Kumiko Tokushima University
Ueno, Rie Tokushima University
Todoroki, Takafumi Tokushima University
Shimabukuro, Michio Tokushima University|Fukushima Medical University KAKEN Search Researchers
Keywords
Polyunsaturated fatty acids
Eicosapentaenoic acid
Docosahexaenoic acid
In-stent restenosis
Content Type
Journal Article
Description
Aim: It is speculated that statin therapy modulates the synthesis of polyunsaturated fatty acids (PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). However, the data available on the effects of statin therapy on the serum levels of PUFA and the subsequent impact on in-stent restenosis (ISR) in patients with acute coronary syndrome (ACS) are limited.
Methods: A total of 120 ACS patients who received emergent coronary stent implantation, follow-up coronary angiography to evaluate ISR, and new statin therapy were enrolled. We measured the serum levels of the PUFA and lipids at the onset of ACS and at the follow-up coronary angiography.
Results: The follow-up coronary angiography revealed 38 ISR cases. New statin therapy significantly reduced the serum levels of DHA and low-density lipoprotein cholesterol (LDL-C), while it did not affect EPA level. Single regression analysis revealed that a decreased serum level of LDL-C was associated with decreased DHA level. The multiple logistic regression analysis revealed that the decreased DHA level after statin therapy and low serum level of EPA on admission were determinants of prevalence of ISR.
Conclusion: Statin therapy decreased the serum level of DHA with a parallel reduction in LDL-C level in patients with ACS. Decreased DHA level after statin therapy and low EPA level on admission are risk factors for ISR, indicating that in patients with ACS, decreased serum levels of DHA may be a residual target for the prevention of ISR.
Journal Title
Journal of Atherosclerosis and Thrombosis
ISSN
18803873
13403478
Publisher
Japan Atherosclerosis Society
Volume
26
Issue
3
Start Page
272
End Page
281
Published Date
2019-03-01
Rights
Copyright©2019 Japan Atherosclerosis Society
This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.(https://creativecommons.org/licenses/by-nc-sa/4.0/)
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DOI (Published Version)
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language
eng
TextVersion
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departments
Medical Sciences
University Hospital