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ID 113222
Title Alternative
Frailty and Diastolic Dysfunction
Author
Okushi, Yuichiro Tokushima University
Nishio, Susumu Tokushima University
Torii, Yuta Tokushima University
Hirata, Yukina Tokushima University
Saijo, Yoshihito Tokushima University
Keywords
Diastolic function
Elderly patient
Frailty
Prognosis
Content Type
Journal Article
Description
Background: High prevalence of frailty and of diastolic dysfunction (DD) in heart failure and high mortality in frail adults have been noted. We characterized frailty by quantifying differences on echocardiography, and assessed the added prognostic utility of frailty and DD grade in an elderly population.
Methods and Results: One hundred and ninety-one patients ≥65 years who had at least 1 cardiovascular risk factor were prospectively recruited for clinically indicated echocardiography at the present institute. Weight loss, exhaustion, and deficits in physical activity, gait speed, and handgrip strength were used to categorize patients as frail (≥3 features), intermediately frail (1 or 2 features), or non-frail (0 features). DD grade ≥2 was defined as severe. Frailty was associated with larger left atrial volume, smaller stroke volume, and worse DD grade after adjustment for age. In a period of 14 months, 29 patients (15%) had cardiovascular events. The addition of frailty score and severe DD significantly improved the prognostic power of a model containing male gender (model 1, male gender, χ2=6.4; model 2, model 1 plus frailty score, χ2=16.7, P=0.004; model 3, model 2 plus severe DD, χ2=25.5, P=0.015).
Conclusions: Both frailty and DD grade were significantly associated with future cardiovascular events in an elderly population with preserved ejection fraction and ≥1 risk factor of cardiovascular disease.
Journal Title
Circulation Journal
ISSN
13469843
13474820
NCID
AA11591968
Publisher
The Japanese Circulation Society
Volume
82
Issue
8
Start Page
2103
End Page
2110
Published Date
2018-04-28
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
University Hospital
Medical Sciences