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ID 113350
Title Alternative
高血圧性心疾患における左室拡張期電気機械的カップリングの非侵襲的評価法
Electromechanical Coupling in HHD
Author
Saito, Yuko Tokushima University
Keywords
Tpeak-Tend interval
E/e'
hypertension
diastolic electromechanical coupling
Content Type
Thesis or Dissertation
Description
Background: There is a need to stratify patients who may develop heart failure because of the current “heart failure pandemic”. We hypothesized that noninvasive assessment of diastolic electromechanical coupling by electrocardiography and Doppler echocardiography may be clinically useful for risk stratification of hypertensive patients who may develop heart failure.
Methods: We measured the time from the peak to end of the T-wave (TpTe) as an electrophysiological parameter, and peak early-diastolic mitral flow (E) and lateral annular (e’) velocities as mechanical parameters in 109 patients with hypertension. Relationships between these parameters and their association with the prognosis was evaluated.
Results: The e’ was inversely correlated with TpTe (p<0.001) and QTc (p < 0.014), whereas E/e’ was positively correlated with TpTe (p<0.001) and QTc (p<0.001). The TpTe predicted patients with E/e’ > 12. There were 24 cardiovascular events during follow-up (57 ± 20 months), and Kaplan-Meir analysis showed that outcome was worse (p=0.003) in patients with higher E/e’ than lower E/e’, however, there was no difference between patients with longer TpTe (≧72 msec) and shorter TpTe (<72 msec).
Conclusions: The correlation of TpTe with e’ and E/e’ in hypertensive patients suggests that these parameters reflect diastolic ventricular electromechanical coupling. The E/e’ predicted outcome, and an elevated E/e’ should be suspected when TpTe is prolonged (> 72 msec). Noninvasive evaluation of diastolic electromechanical coupling is clinically useful in patients with hypertension.
Journal Title
Journal of Echocardiography
ISSN
13490222
1880344X
NCID
AA12042477
AA12047288
Publisher
Japanese Society of Echocardiography|Springer nature
Volume
17
Issue
4
Start Page
206
End Page
212
Published Date
2019-02-12
Remark
内容要旨・審査要旨・論文要約の公開
本文全文は後日公開予定。
The final publication is available at link.springer.com: https://doi.org/10.1007/s12574-019-00421-4
本論文は, 著者Yuko Saitoの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
jpn
TextVersion
その他
MEXT report number
甲第3266号
Diploma Number
甲医第1415号
Granted Date
2019-03-19
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences