Iizuka, Shinji Sanford-Burnham Medical Research Institute
Ishimaru, Naozumi The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kudo, Yasusei The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
head and neck squamous cell carcinoma
Extracellular matrix degradation by matrix metalloproteinases (MMPs) plays a pivotal role in cancer progression by promoting motility, invasion and angiogenesis. Studies have shown that MMP expression is increased in head and neck squamous cell carcinomas (HNSCCs), one of the most common cancers in the world, and contributes to poor outcome. In this review, we examine the expression pattern of MMPs in HNSCC by microarray datasets and summarize the current knowledge of MMPs, specifically MMP-1, -3, -7 -10, -12, -13, 14 and -19, that are highly expressed in HNSCCs and involved cancer invasion and angiogenesis.
© 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
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cancers_6_1_396.pdf 631 KB