Total for the last 12 months
number of access : ?
number of downloads : ?
ID 113644
Author
Fukushima, Shu-ichiro Osaka University
Yonetsu, Makoto Osaka University
Keywords
skin
photoaging
collagen
wrinkle
orientation
second-harmonic-generation microscopy
Content Type
Journal Article
Description
Skin wrinkling is a typical symptom of cutaneous photoaging; however, the skin wrinkling depends on not only the actual age but also exposure history to ultraviolet B (UVB) rays in individuals. Therefore, there is considerable need for its assessment technique in vivo in skin cosmetics and antiaging dermatology. Wrinkles always appear as linear grooves in the skin, and dermal collagen fibers play an important role to determine the morphology and mechanical properties of the skin. Therefore, an optical probe sensitive to dermal collagen fiber and its orientation will be useful. Polarization-resolved second-harmonic-generation (SHG) microscopy is a promising approach for in vivo evaluation of collagen fiber orientation because the efficiency of SHG light is sensitive to collagen fiber orientation when the incident light is linearly polarized. We investigate orientation change of dermal collagen fiber in prewrinkled and wrinkled skins of the UVB-exposed mouse model using polarization-resolved SHG microscopy. A polarization anisotropic image of the SHG light indicates that the change of collagen fiber orientation starts in the prewrinkled skin of UVB-exposed mice, then the wrinkle appears. Furthermore, the dominant direction of collagen fiber orientation in the prewrinkled skin is significantly parallel to the wrinkle direction in the wrinkled skin. This result implies that the change of collagen fiber orientation is a trigger of wrinkling in cutaneous photoaging.
Journal Title
Journal of Biomedical Optics
ISSN
10833668
15602281
NCID
AA11237889
AA11953151
Publisher
SPIE
Volume
24
Issue
3
Start Page
031006
Published Date
2018-09-06
Rights
© The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License(https://creativecommons.org/licenses/by/3.0/). Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI. [DOI: 10.1117/1.JBO.24.3.031006]
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Science and Technology