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ID 113737
Title Alternative
Cortical thymic epithelial cells
Author
Kozai, Mina University of Tokushima KAKEN Search Researchers
Keywords
thymus
cortex
cortical thymic epithelial cell
positive selection
thymic epithelial progenitor
Content Type
Journal Article
Description
The thymic cortex provides a microenvironment for the development and positive selection of immature T cells. Cortical thymic epithelial cells (cTECs), which structurally and functionally support the thymic cortical microenvironment, originate from endodermal epithelial progenitors that arise in the third pharyngeal pouch. Recent studies have revealed that thymic epithelial progenitors pass through a stage where the cells express cTEC-associated molecules prior to lineage separation into cTECs and medullary TECs (mTECs). Here we review the molecular signatures of cTECs and highlight the development and developmental potential of cTECs.
Journal Title
Immunological Reviews
ISSN
1600065X
01052896
NCID
AA00670246
Publisher
John Wiley & Sons
Volume
271
Issue
1
Start Page
10
End Page
22
Published Date
2016-04-18
Rights
This is the peer-reviewed version of the following article: Ohigashi, I. , Kozai, M. and Takahama, Y. (2016), Development and developmental potential of cortical thymic epithelial cells. Immunol Rev, 271: 10-22, which has been published in final form at https://doi.org/10.1111/imr.12404. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
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DOI (Published Version)
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language
eng
TextVersion
Author
departments
Institute of Advanced Medical Sciences