Ohigashi, Izumi University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Zuklys, Saulius University of Basel|University Children’s Hospital Basel
Sakata, Mie University of Tokushima
Mayer, Carlos E. University of Basel|University Children’s Hospital Basel
Hamazaki, Yoko Kyoto University
Minato, Nagahiro Kyoto University
Hollander, Georg A. University of Basel|University Children’s Hospital Basel|University of Oxford
Takahama, Yousuke University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Medullary thymic epithelial cells (mTECs) play an essential role in establishing self-tolerance in T cells. mTECs originate from bipotent TEC progenitors that generate both mTECs and cortical TECs (cTECs), although mTEC-restricted progenitors also have been reported. Here, we report in vivo fate-mapping analysis of cells that transcribe β5t, a cTEC trait expressed in bipotent progenitors, during a given period in mice. We show that, in adult mice, most mTECs are derived from progenitors that transcribe β5t during embryogenesis and the neonatal period up to 1 week of age. The contribution of adult β5t+ progenitors was minor even during injury-triggered regeneration. Our results further demonstrate that adult mTEC-restricted progenitors are derived from perinatal β5t+ progenitors. These results indicate that the adult thymic medullary epithelium is maintained and regenerated by mTEC-lineage cells that pass beyond the bipotent stage during early ontogeny.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
|DOI (Published Version)|
|URL ( Publisher's Version )|
celrep_13_7_1432.pdf 3.75 MB
Institute of Advanced Medical Sciences