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ID 113738
Author
Zuklys, Saulius University of Basel|University Children’s Hospital Basel
Sakata, Mie University of Tokushima
Mayer, Carlos E. University of Basel|University Children’s Hospital Basel
Hamazaki, Yoko Kyoto University
Minato, Nagahiro Kyoto University
Hollander, Georg A. University of Basel|University Children’s Hospital Basel|University of Oxford
Content Type
Journal Article
Description
Medullary thymic epithelial cells (mTECs) play an essential role in establishing self-tolerance in T cells. mTECs originate from bipotent TEC progenitors that generate both mTECs and cortical TECs (cTECs), although mTEC-restricted progenitors also have been reported. Here, we report in vivo fate-mapping analysis of cells that transcribe β5t, a cTEC trait expressed in bipotent progenitors, during a given period in mice. We show that, in adult mice, most mTECs are derived from progenitors that transcribe β5t during embryogenesis and the neonatal period up to 1 week of age. The contribution of adult β5t+ progenitors was minor even during injury-triggered regeneration. Our results further demonstrate that adult mTEC-restricted progenitors are derived from perinatal β5t+ progenitors. These results indicate that the adult thymic medullary epithelium is maintained and regenerated by mTEC-lineage cells that pass beyond the bipotent stage during early ontogeny.
Journal Title
Cell Reports
ISSN
22111247
Publisher
Elsevier
Volume
13
Issue
7
Start Page
1432
End Page
1443
Published Date
2015-11-05
Rights
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Institute of Advanced Medical Sciences