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ID 113951
Author
Keywords
Pulmonary arterial hypertension
Potassium channel
Smooth muscle cell
Vascular remodeling
Content Type
Journal Article
Description
Many different types of potassium channels with various functions exist in pulmonary artery smooth muscle cells, contributing to many physiological actions and pathological conditions. The deep involvement of these channels in the onset and exacerbation of pulmonary arterial hypertension (PAH) also continues to be revealed. In 2013, KCNK3 (TASK1), which encodes a type of two-pore domain potassium channel, was shown to be a predisposing gene for PAH by genetic mutation, and it was added to the PAH classification at the Fifth World Symposium on Pulmonary Hypertension (Nice International Conference). Decreased expression and inhibited activity of voltage-gated potassium channels, particularly KCNA5 (Kv1.5), are also seen in PAH, regardless of the cause, and facilitation of pulmonary arterial contraction and vascular remodeling has been shown. The calcium-activated potassium channels seen in smooth muscle cells also change from BKca (Kca1.1) to IKca (Kca3.1) predominance in PAH due to transformation, and have effects including the facilitation of smooth muscle cell migration, enhancement of proliferation, and inhibition of apoptosis. Elucidation of these roles for potassium channels in pulmonary vasoconstriction and remodeling may help bring new therapeutic strategies into view.
Journal Title
Pediatric Cardiology
ISSN
01720643
14321971
NCID
AA00361536
Publisher
Springer US
Volume
38
Issue
1
Start Page
1
End Page
14
Published Date
2016-11-08
Remark
This is a post-peer-review, pre-copyedit version of an article published in Pediatric Cardiology. The final authenticated version is available online at: https://doi.org/10.1007/s00246-016-1491-7.
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DOI (Published Version)
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language
eng
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Author
departments
Medical Sciences