Dynapenia and AGEs in type 2 diabetes
Mori, Hiroyasu Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kuroda, Akio Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Ishizu, Masashi Tokushima University
Ohishi, Mami Tokushima University
Takashi, Yuichi Tokushima University
Otsuka, Yinhua Tokushima University
Kurahashi, Kiyoe Tokushima University Tokushima University Educator and Researcher Directory
Endo, Itsuro Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Aihara, Ken-ichi Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Funaki, Makoto Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Akehi, Yuko Tokushima University
Advanced glycation end-products
Thesis or Dissertation
Aims/Introduction: Advanced glycation end-products (AGEs), which are a major cause of diabetic vascular complications, accumulate in various tissues under chronic hyperglycemic conditions, as well as with aging in patients with diabetes. The loss of muscle mass and strength, so-called sarcopenia and dynapenia, has recently been recognized as a diabetic complication. However, the influence of accumulated AGEs on muscle mass and strength remains unclear. The present study aimed to evaluate the association of sarcopenia and dynapenia with accumulated AGEs in patients with type 2 diabetes.
Materials and Methods: We recruited 166 patients with type 2 diabetes aged ≥30 years (mean age 63.2 ± 12.3 years; body mass index 26.3 ± 4.9 kg/m2; glycated hemoglobin 7.1 ± 1.1%). Skin autofluorescence as a marker of AGEs, limb skeletal muscle mass index, grip strength, knee extension strength and gait speed were assessed.
Results: Sarcopenia and dynapenia were observed in 7.2 and 13.9% of participants, respectively. Skin autofluorescence was significantly higher in patients with sarcopenia and dynapenia. Skin autofluorescence was the independent determinant for skeletal muscle mass index, grip strength, knee extension strength, sarcopenia and dynapenia.
Conclusions: Accumulated AGEs could contribute to reduced muscle mass and strength, leading to sarcopenia and dynapenia in patients with type 2 diabetes.
Journal of Diabetes Investigation
Asian Association for the Study of Diabetes|John Wiley & Sons Australia
© 2019 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License(https://creativecommons.org/licenses/by-nc/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
|DOI (Published Version)|
|URL ( Publisher's Version )|
o2114_abstract_review.pdf 279 KB
o2114_fulltext.pdf 373 KB
|MEXT report number||
Doctor of Medical Science
Institute of Advanced Medical Sciences