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ID 114188
Title Alternative
Blood Pressure and Arterial Stiffness
Tomiyama, Hirofumi Tokyo Medical University
Ohkuma, Toshiaki Kyushu University
Ninomiya, Toshiharu Kyushu University
Nakano, Hiroki Tokyo Medical University
Matsumoto, Chisa Tokyo Medical University
Avolio, Alberto Macquarie University
Kohro, Takahide Jichi Medical University
Higashi, Yukihito Hiroshima University
Maruhashi, Tatsuya Hiroshima University
Takase, Bonpei National Defense Medical College
Suzuki, Toru University of Leicester
Ishizu, Tomoko University of Tsukuba
Ueda, Shinichiro University of the Ryukyus
Yamazaki, Tsutomu The University of Tokyo
Furumoto, Tomoo Hokkaido University
Kario, Kazuomi Jichi Medical University
Inoue, Teruo Dokkyo Medical University
Koba, Shinji Showa University
Takemoto, Yasuhiko Osaka City University
Hano, Takuzo Wakayama Medical University
Ishibashi, Yutaka Shimane University
Node, Koichi Saga University
Maemura, Koji Nagasaki University
Ohya, Yusuke University of the Ryukyus
Furukawa, Taiji Teikyo University
Ito, Hiroshi Okayama University
Chikamori, Taishiro Tokyo Medical University
Yamashina, Akira Tokyo Medical University
arterial stiffness
blood pressure
organ damage
stiffness index β
Content Type
Journal Article
Background—The difference in the predictive ability of the brachial-ankle pulse wave velocity (baPWV) and its stiffness index β-transformed value (β-baPWV, ie, baPWV adjusted for the pulse pressure) for the development of pathophysiological abnormalities related to cardiovascular disease or future occurrence of cardiovascular disease was examined.
Methods and Results—In study 1, a 7-year prospective observational study in cohorts of 3274 men and 3490 men, the area under the curve in the receiver operator characteristic curve analysis was higher for baPWV than for β-baPWV for predicting the development of hypertension (0.73, 95% CI=0.70 to 0.75 versus 0.59, 95% CI=0.56 to 0.62; P<0.01) and/or the development of retinopathy (0.78, 95% CI=0.73 to 0.82 versus 0.66, 95% CI=0.60 to 0.71; P<0.01) by the end of the study period. During study 2, a 3-year observation period on 511 patients with coronary artery disease, 72 cardiovascular events were confirmed. The C statistics of both markers for predicting the development of cardiovascular events were similar.
Conclusions—Stiffness index β transformation of the baPWV may attenuate the significance of the baPWV as a risk marker for development of pathophysiological abnormalities related to cardiovascular disease in male subjects.
Journal Title
Journal of the American Heart Association
The American Heart Association
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© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License(, which permits use and distribution in any medium, provided the original work is properly cited, the use is noncommercial and no modifications or adaptations are made.
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Medical Sciences