Yamamoto, Tetsuya University of Pittsburgh|Japan Society for the Promotion of Science|Tokushima University Tokushima University Educator and Researcher Directory
Toki, Shigeru Hiroshima University
Siegle, Greg J. University of Pittsburgh|Western Psychiatric Institute and Clinic
Takamura, Masahiro Hiroshima University
Takaishi, Yoshiyuki Hiroshima University
Yoshimura, Shinpei Otemon Gakuin University
Okada, Go Hiroshima University
Matsumoto, Tomoya Hiroshima University
Nakao, Takashi Hiroshima University
Muranaka, Hiroyuki Tsukuba International University
Kaseda, Yumiko Hiroshima City General Rehabilitation Center
Murakami, Tsuneji Kure Kyosai Hospital
Okamoto, Yasumasa Hiroshima University
Yamawaki, Shigeto Hiroshima University
Early life stress
Background: Amygdala hyper-reactivity is sometimes assumed to be a vulnerability factor that predates depression; however, in healthy people, who experience early life stress but do not become depressed, it may represent a resilience mechanism. We aimed to test these hypothesis examining whether increased amygdala activity in association with a history of early life stress (ELS) was negatively or positively associated with depressive symptoms and impact of negative life event stress in never-depressed adults.
Methods: Twenty-four healthy participants completed an individually tailored negative mood induction task during functional magnetic resonance imaging (fMRI) assessment along with evaluation of ELS.
Results: Mood change and amygdala reactivity were increased in never-depressed participants who reported ELS compared to participants who reported no ELS. Yet, increased amygdala reactivity lowered effects of ELS on depressive symptoms and negative life events stress. Amygdala reactivity also had positive functional connectivity with the bilateral DLPFC, motor cortex and striatum in people with ELS during sad memory recall.
Conclusions: Increased amygdala activity in those with ELS was associated with decreased symptoms and increased neural features, consistent with emotion regulation, suggesting that preservation of robust amygdala reactions may reflect a stress buffering or resilience enhancing factor against depression and negative stressful events.
BioMed Central|Springer Nature
© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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Integrated Arts and Sciences