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ID 114736
Title Alternative
妊娠中の血清ビオチン濃度は胎児の成長と早産に関連する
Serum biotin level during pregnancy
Author
Ichihara, Yuko Tokushima University|Tokushima Municipal Hospital
Fukui, Maika Tokushima University
Yonetani, Naoto Tokushima University
Shono, Miki Tokushima University
Keywords
biotin
pregnancy
preterm birth
fetal growth restriction
small for gestational age
Content Type
Thesis or Dissertation
Description
Background : Biotin is a water-soluble vitamin that plays various biological roles through histone modification, such as immune functions and fetal growth. Mammalian maternal biotin deficiency during gestation induces fetal growth restriction. Preterm infants are known to be marginal biotin deficiency. However, studies on the biotin status of pregnant women under various conditions are lacking. Method : This was a retrospective case control study to analyze serum biotin concentration during pregnancy and cord blood in normal pregnancy, preterm delivery and small-for-gestational-age (SGA). Results : Twenty pregnant women with normal term delivery, 35 with preterm delivery, 24 with SGA, and 10 non-pregnant adult women were enrolled. Serum biotin concentrations of pregnant women remained low from first to third trimester. The levels of serum biotin in cord blood showed a significant positive correlation with gestational age, and that of pregnant women showed a weak positive correlation with gestational age. The maternal serum biotin levels during second and third trimester of SGA group were significantly lower than those of normal term delivery. Conclusion : This study suggests that maternal biotin deficiency during pregnancy might be the risk of preterm labor or fetal growth restriction. Further studies are required to clarify the roles of biotin in perinatal medicine.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA12022913
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
67
Issue
1-2
Start Page
170
End Page
173
Sort Key
170
Published Date
2020-02
Remark
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Yuko Ichiharaの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3368号
Diploma Number
甲医第1451号
Granted Date
2020-03-18
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences