Total for the last 12 months
number of access : ?
number of downloads : ?
ID 114774
Title Alternative
Diagnostic Criteria of FMD and NID
Maruhashi, Tatsuya Hiroshima University
Kajikawa, Masato Hiroshima University
Kishimoto, Shinji Hiroshima University
Hashimoto, Haruki Hiroshima University
Takaeko, Yuji Hiroshima University
Yamaji, Takayuki Hiroshima University
Harada, Takahiro Hiroshima University
Han, Yiming Hiroshima University
Aibara, Yoshiki Hiroshima University
Mohamad Yusoff, Farina Hiroshima University
Hidaka, Takayuki Hiroshima University
Kihara, Yasuki Hiroshima University
Chayama, Kazuaki Hiroshima University
Nakashima, Ayumu Hiroshima University
Goto, Chikara Hiroshima International University
Tomiyama, Hirofumi Tokyo Medical University
Takase, Bonpei National Defense Medical College
Kohro, Takahide Jichi Medical University
Suzuki, Toru University of Leicester
Ishizu, Tomoko University of Tsukuba
Ueda, Shinichiro University of the Ryukyu
Yamazaki, Tsutomu The University of Tokyo
Furumoto, Tomoo Hokkaido University
Kario, Kazuomi Jichi Medical University
Inoue, Teruo Dokkyo Medical University
Koba, Shinji Showa University
Watanabe, Kentaro Yamagata University
Takemoto, Yasuhiko Osaka City University
Hano, Takuzo Wakayama Medical University
Ishibashi, Yutaka Shimane University
Node, Koichi Saga University
Maemura, Koji Nagasaki University
Ohya, Yusuke University of the Ryukyus
Furukawa, Taiji Teikyo University
Ito, Hiroshi Okayama University
Ikeda, Hisao Teikyo University
Yamashina, Akira Hiroshima International University
Higashi, Yukihito Hiroshima University
diagnostic criteria
endothelial function
flow-mediated vasodilation
nitroglycerin-induced vasodilation
vascular smooth muscle function
Content Type
Journal Article
Background - Diagnostic criteria of flow-mediated vasodilation (FMD), an index of endothelial function, and nitroglycerin-induced vasodilation (NID), an index of vascular smooth muscle function, of the brachial artery have not been established. The purpose of this study was to propose diagnostic criteria of FMD and NID for normal endothelial function and normal vascular smooth muscle function.
Methods and Results - We investigated the cutoff values of FMD and NID in subjects with (risk group) and those without cardiovascular risk factors or cardiovascular diseases (no-risk group) in 7277 Japanese subjects (mean age 51.4±10.8 years) from the Flow-Mediated Dilation Japan study and the Flow-Mediated Dilatation Japan Registry study for analysis of the cutoff value of FMD and in 1764 Japanese subjects (62.2±16.1 years) from the registry of Hiroshima University Hospital for analysis of the cutoff value of NID. Receiver-operator characteristic curve analysis of FMD to discriminate subjects in the no-risk group from patients in the risk group showed that the optimal cutoff value of FMD to diagnose subjects in the no-risk group was 7.1%. Receiver-operator characteristic curve analysis of NID to discriminate subjects in the no-risk group from patients in the risk group showed that the optimal cutoff value of NID to diagnose subjects in the no-risk group was 15.6%.
Conclusions - We propose that the cutoff value for normal endothelial function assessed by FMD of the brachial artery is 7.1% and that the cutoff value for normal vascular smooth muscle function assessed by NID of the brachial artery is 15.6% in Japanese subjects.
Journal Title
Journal of the American Heart Association
The American Heart Association
Start Page
Published Date
© 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (, which permits use and distribution in any medium, provided the original work is properly cited, the use is noncommercial and no modifications or adaptations are made.
DOI (Published Version)
URL ( Publisher's Version )
FullText File
Medical Sciences