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ID 115126
Author
Keywords
B-vitamins
Distal gut
Gut microbiota
Content Type
Journal Article
Description
The gut microbiota produce hundreds of bioactive compounds, including B-vitamins, which play significant physiological roles in hosts by supporting the fitness of symbiotic species and suppressing the growth of competitive species. B-vitamins are also essential to the host and certain gut bacterium. Although dietary B-vitamins are mainly absorbed from the small intestine, excess B-vitamins unable to be absorbed in the small intestine are supplied to the distal gut. In addition, B-vitamins are supplied from biosynthesis by distal gut microbiota. B-vitamins in the distal colon may perform many important functions in the body; they act as (1) nutrients for a host and their microbiota, (2) regulators of immune cell activity, (3) mediators of drug efficacy, (4) supporters of survival, or the fitness of certain bacterium, (5) suppressors of colonization by pathogenic bacteria, and (6) modulators of colitis. Insights into basic biophysical principles, including the bioavailability of B-vitamins and their derivatives in the distal gut are still not fully elucidated. Here we briefly review the function of single B-vitamin in the distal gut including their roles in relation to bacteria. The prospect of extending analytical methods to better understand the role of B-vitamins in the gut is also explored.
Journal Title
Molecular Nutrition & Food Research
ISSN
16134133
16134125
NCID
AA12809751
AA11974242
Publisher
Wiley
Volume
64
Issue
18
Start Page
2000426
Published Date
2020-08-06
Remark
論文本文は2021-08-19以降公開予定
Rights
This is the peer reviewed version of the following article: Uebanso, T., Shimohata, T., Mawatari, K., Takahashi, A., Functional Roles of B‐Vitamins in the Gut and Gut Microbiome. Mol. Nutr. Food Res. 2020, 64, 2000426., which has been published in final form at https://doi.org/10.1002/mnfr.202000426. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
DOI (Published Version)
URL ( Publisher's Version )
language
eng
TextVersion
その他
departments
Medical Sciences