ID | 115246 |
Author |
Fujiwara, Natsumi
Tokushima University|Augusta University
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Kitamura, Naoya
Kochi University
Yoshida, Kaya
Tokushima University
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Yamamoto, Tetsuya
Kochi University
Ozaki, Kazumi
Tokushima University
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Kudo, Yasusei
Tokushima University
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Keywords | Fusobacterium nucleatum
oral cancer
cancer development and progression
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Content Type |
Journal Article
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Description | Chronic inflammation caused by infections has been suggested to be one of the most important cause of cancers. It has recently been shown that there is correlation between intestinal bacteria and cancer development including metastasis. As over 700 bacterial species exist in an oral cavity, it has been concerning that bacterial infection may cause oral cancer. However, the role of bacteria regarding tumorigenesis of oral cancer remains unclear. Several papers have shown that Fusobacterium species deriving the oral cavities, especially, play a crucial role for the development of colorectal and esophageal cancer. F. nucleatum is a well-known oral bacterium involved in formation of typical dental plaque on human teeth and causing periodontal diseases. The greatest characteristic of F. nucleatum is its ability to adhere to various bacteria and host cells. Interestingly, F. nucleatum is frequently detected in oral cancer tissues. Moreover, detection of F. nucleatum is correlated with the clinical stage of oral cancer. Although the detailed mechanism is still unclear, Fusobacterium species have been suggested to be associated with cell adhesion, tumorigenesis, epithelial-to-mesenchymal transition, inflammasomes, cell cycle, etc. in oral cancer. In this review, we introduce the reports focused on the association of Fusobacterium species with cancer development and progression including oral, esophageal, and colon cancers.
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Journal Title |
International Journal of Molecular Sciences
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ISSN | 14220067
16616596
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Publisher | MDPI
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Volume | 21
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Issue | 17
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Start Page | 6207
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Published Date | 2020-08-27
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Rights | © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
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TextVersion |
Publisher
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departments |
Oral Sciences
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