Control of Thymic Growth
Cowan, Jennifer E. National Institutes of Health
Takahama, Yousuke National Institutes of Health Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Bhandoola, Avinash National Institutes of Health
Ohigashi, Izumi University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Thymus involution occurs in all vertebrates. It is thought to impact on immune responses in the aged, and in other clinical circumstances such as bone marrow transplantation. Determinants of thymus growth and size are beginning to be identified. Ectopic expression of factors like cyclin D1 and Myc in thymic epithelial cells (TEC)s results in considerable increase in thymus size. These models provide useful experimental tools that allow thymus function to be understood. In future, understanding TEC-specific controllers of growth will provide new approaches to thymus regeneration.
Frontiers in Immunology
Frontiers Media S.A.
This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY) ( https://creativecommons.org/licenses/by/4.0/ ). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
|DOI (Published Version)|
|URL ( Publisher's Version )|
fimmu_11_897.pdf 603 KB
Institute of Advanced Medical Sciences