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ID 115261
Title Alternative
Control of Thymic Growth
Author
Cowan, Jennifer E. National Institutes of Health
Bhandoola, Avinash National Institutes of Health
Keywords
thymus
Myc
cyclin D1
growth
involution
aging
Content Type
Journal Article
Description
Thymus involution occurs in all vertebrates. It is thought to impact on immune responses in the aged, and in other clinical circumstances such as bone marrow transplantation. Determinants of thymus growth and size are beginning to be identified. Ectopic expression of factors like cyclin D1 and Myc in thymic epithelial cells (TEC)s results in considerable increase in thymus size. These models provide useful experimental tools that allow thymus function to be understood. In future, understanding TEC-specific controllers of growth will provide new approaches to thymus regeneration.
Journal Title
Frontiers in Immunology
ISSN
16643224
Publisher
Frontiers Media S.A.
Volume
11
Start Page
897
Published Date
2020-05-12
Rights
This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY) ( https://creativecommons.org/licenses/by/4.0/ ). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Institute of Advanced Medical Sciences