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ID 115397
Title Alternative
性別に基づく血清葉酸濃度と統合失調症との関連
Folate and sex in schizophrenia
Association between serum folate levels and schizophrenia based on gender
Folate and gender in schizophrenia
Author
Keywords
統合失調症
葉酸
ホモシステイン
ビタミンB6
folate
homocysteine
pyridoxal
schizophrenia
vitamin B6
Content Type
Thesis or Dissertation
Description
Aim: Gender differences in serum folate concentrations are well known, but no studies have investigated the association between serum folate levels and schizophrenia based on gender. In this study in a Japanese population, we examined the difference in serum folate levels between patients with schizophrenia and non‐psychiatric controls stratified by gender. The relationships between serum folate levels, plasma total homocysteine (tHcy) and serum vitamin B6 (pyridoxal) levels were also examined using data from our previous studies.
Methods: The serum folate concentrations of 482 patients diagnosed with schizophrenia and 1,350 non‐psychiatric control subjects were measured. We conducted an analysis of covariance to examine the differences in serum folate levels between the two groups based on gender. Spearman’s rank correlation was used to evaluate the relationships between folate, tHcy and vitamin B6 levels.
Results: In the control group, serum folate concentrations were higher in women than in men. Lower levels of serum folate were observed in both male and female patients with schizophrenia. An inverse correlation between serum folate and plasma tHcy and a weak positive correlation between serum folate and vitamin B6 were observed in the combined cohort.
Conclusion: Our findings suggest that (1) a low serum folate level may be associated with schizophrenia regardless of gender, and (2) folate administration may be beneficial for the treatment of schizophrenia. In schizophrenic patients with low serum folate levels, folate administration might result in improvements in high tHcy and an increase in low vitamin B6 levels.
Journal Title
Psychiatry and Clinical Neurosciences
ISSN
13231316
14401819
NCID
AA11040669
Publisher
Wiley|Japanese Society of Psychiatry and Neurology
Volume
74
Issue
9
Start Page
466
End Page
471
Published Date
2020-05-23
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Yukiko Tomiokaの学位論文として提出され,学位審査・授与の対象となっている。
Rights
This is the peer reviewed version of the following article: Tomioka, Y., Kinoshita, M., Umehara, H., Nakayama, T., Watanabe, S.‐y., Nakataki, M., Numata, S. and Ohmori, T. (2020), Association between serum folate levels and schizophrenia based on sex. Psychiatry Clin. Neurosci., 74: 466-471, which has been published in final form at https://doi.org/10.1111/pcn.13074.
This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3464号
Diploma Number
甲医第1470号
Granted Date
2020-10-22
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences