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ID 115539
Title Alternative
Stress and radiation hematopoietic toxicity
Author
Wang, Bing National Institute of Radiological Sciences
Tanaka, Kaoru National Institute of Radiological Sciences
Katsube, Takanori National Institute of Radiological Sciences
Ninomiya, Yasuharu National Institute of Radiological Sciences
Vares, Guillaume National Institute of Radiological Sciences
Liu, Qiang Chinese Academy of Medical Sciences and Peking Union Medical College
Nakajima, Tetsuo National Institute of Radiological Sciences
Nenoi, Mitsuru National Institute of Radiological Sciences
Keywords
chronic restraint-induced stress
total-body irradiation
peripheral blood hemogram
bone marrow micronucleated erythrocytes
mouse restraint model
Content Type
Journal Article
Description
Both radiation and stresses cause detrimental effects on humans. Besides possible health effects resulting directly from radiation exposure, the nuclear plant accident is a cause of social psychological stresses. A recent study showed that chronic restraint-induced stresses (CRIS) attenuated Trp53 functions and increased carcinogenesis susceptibility of Trp53 -heterozygous mice to total-body X-irradiation (TBXI), having a big impact on the academic world and a sensational effect on the public, especially the residents living in radioactively contaminated areas. It is important to investigate the possible modification effects from CRIS on radiation-induced health consequences in Trp53 wild-type (Trp53 wt) animals. Prior to a carcinogenesis study, effects of TBXI on the hematopoietic system under CRIS were investigated in terms of hematological abnormality in the peripheral blood and residual damage in the bone marrow erythrocytes using a mouse restraint model. Five-week-old male Trp53 wt C57BL/6J mice were restrained 6 h per day for 28 consecutive days, and TBXI (4 Gy) was given on the 8th day. Results showed that CRIS alone induced a marked decrease in the red blood cell (RBC) and the white blood cell (WBC) count, while TBXI caused significantly lower counts of RBCs, WBCs and blood platelets, and a lower concentration of hemoglobin regardless of CRIS. CRIS alone did not show any significant effect on erythrocyte proliferation and on induction of micronucleated erythrocytes, whereas TBXI markedly inhibited erythrocyte proliferation and induced a significant increase in the incidences of micronucleated erythrocytes, regardless of CRIS. These findings suggest that CRIS does not have a significant impact on radiation-induced detrimental effects on the hematopoietic system in Trp53 wt mice.
Journal Title
Journal of Radiation Research
ISSN
13499157
NCID
AA00705792
Publisher
Oxford University Press|The Japanese Radiation Research Society|Japanese Society for Radiation Oncology
Volume
56
Issue
5
Start Page
760
End Page
767
Published Date
2015-06-04
Rights
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
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DOI (Published Version)
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language
eng
TextVersion
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departments
Medical Sciences