number of access : ?
number of downloads : ?
ID 115653
Author
Suga, Yosuke Kochi University
Yoshimoto, Keiichiro Watarigawa Hospital
Shimodera, Shinji Ginza Shimodera Clinic
Takamura, Shogo Watarigawa Hospital
Kamimura, Naoto Kochi University
Sawada, Ken Kochi University|Kochi Health Sciences Center
Kazui, Hiromitsu Kochi University
Ohmori, Tetsuro The University of Tokushima KAKEN Search Researchers
Morinobu, Shigeru Kochi University|KIBI International University
Keywords
bipolar disorder
brain‐derived neurotrophic factor
copy number variation
glycogen synthase kinase 3®
lithium
Content Type
Journal Article
Description
Background: Lithium is the first‐line drug for the treatment of bipolar disorders (BDs); however, not all patients responded. Glycogen synthase kinase (GSK) 3β and brain‐derived neurotrophic factor (BDNF) play a role in the therapeutic action of lithium. Since structural variations were reported in these genes, it is possible that these genomic variations may be involved in the therapeutic responses to lithium.
Method: Fifty patients with BDs and 50 healthy subjects (mean age 55.0 ± 15.0 years; M/F 19/31) participated. We examined structural variation of the GSK3β and BDNF genes by real‐time PCR. We examined the influence of structural variation of these genes on the therapeutic responses to lithium and the occurrence of antidepressant‐emergent affective switch (AEAS). The efficacy of lithium was assessed using the Alda scale, and AEAS was evaluated using Young Mania Rating Scale.
Results: Although we examined structural variations within intron II and VII of the GSK3® gene and from the end of exon IV to intron IV and within exon IX of the BDNF gene, no structural variation was found in BDs. Whereas 5 of 50 patients exhibited three copies of the genomic region within exon IV of the BDNF gene, all healthy subjects had two copies. No difference in the therapeutic efficacy of lithium was found between patients with three and two copies. No difference in the occurrence of AEAS was found between the two groups.
Conclusion: The amplification of the BDNF gene influenced neither the therapeutic responses to lithium nor the occurrence of AEAS.
Journal Title
Neuropsychopharmacology Reports
ISSN
2574173X
Publisher
The Japanese Society of Neuropsychopharmacology|John Wiley & Sons
Volume
40
Issue
1
Start Page
46
End Page
51
Published Date
2019-11-26
Remark
所属英表記誤記あり (誤)Watarigawa Hostipal→(正)Watarigawa Hospital
Rights
This is an open access article under the terms of the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences