ID | 115809 |
Author |
Kono, Toru
Sapporo Higashi Tokushukai Hospital
Shimada, Mitsuo
Tokushima University
Tokushima University Educator and Researcher Directory
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Nishi, Masaaki
Tokushima University
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Morine, Yuji
Tokushima University
Tokushima University Educator and Researcher Directory
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Katsuno, Hidetoshi
Fujita Health University
Maeda, Koutarou
Fujita Health University
Koeda, Keisuke
Iwate Medical University
Morita, Satoshi
Kyoto University
Watanabe, Masahiko
Kitasato University
Kusano, Mitsuo
Ohta General Hospital Foundation Ohta Atami Hospital
Sakamoto, Junichi
Tokai Central Hospital
Saji, Shigetoyo
Japanese Foundation for Multidisciplinary Treatment of Cancer
Sokuoka, Hiroki
Japanese Foundation for Multidisciplinary Treatment of Cancer
Sato, Yasuto
Tokyo Women’s Medical University
Maehara, Yoshihiko
Japanese Foundation for Multidisciplinary Treatment of Cancer
Kanematsu, Takashi
Nagasaki City Hospital Organization
Kitajima, Masaki
International University of Health and Welfare
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Keywords | Kampo
Body mass index
Postoperative ileus
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Content Type |
Journal Article
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Description | Purpose
Prolonged postoperative ileus (POI) is a common complication after open abdominal surgery (OAS). Daikenchuto (DKT), a traditional Japanese medicine that peripherally stimulates the neurogenic pathway, is used to treat prolonged POI in Japan. To analyze whether DKT accelerates the recovery from prolonged POI after OAS, we conducted a secondary analysis of three multicenter randomized controlled trials (RCTs). Methods A secondary analysis of the three RCTs supported by the Japanese Foundation for Multidisciplinary Treatment of Cancer (project numbers 39-0902, 40-1001, 42-1002) assessing the effect of DKT on prolonged POI in patients who had undergone OAS for colon, liver, or gastric cancer was performed. The subgroup included 410 patients with no bowel movement (BM) before the first diet, a DKT group (n = 214), and a placebo group (n = 196). Patients received either 5 g DKT or a placebo orally, three times a day. The primary endpoint was defined as the time from the end of surgery to the first bowel movement (FBM). A sensitivity analysis was also performed on the age, body mass index and dosage as subgroup analyses. Results The primary endpoint was significantly accelerated in the DKT group compared with the placebo group (p = 0.004; hazard ratio 1.337). The median time to the FBM was 113.8 h in the placebo group and 99.1 h in the DKT treatment group. Conclusions The subgroup analysis showed that DKT significantly accelerated the recovery from prolonged POI following OAS. |
Journal Title |
Surgery Today
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ISSN | 09411291
14362813
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NCID | AA10824685
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Publisher | Japan Surgical Society|Springer Nature
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Volume | 49
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Issue | 8
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Start Page | 704
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End Page | 711
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Published Date | 2019-02-25
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Rights | This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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language |
eng
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departments |
Medical Sciences
University Hospital
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