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ID 115904
Author
Aotani, Nozomi Tokushima University
Kagiya, Natsumi Tokushima University
Takimoto, Mami Tokushima University
Oiwa, Yu Tokushima University
Matsubara, Atsumi Tokushima University
Matsuura, Sayaka Tokushima University
Tanimura, Mayu Tokushima University
Tani-Suzuki, Yoshiko Tokushima University
Keywords
ESPEN diagnostic criteria
Malnutrition
Body mass index
Fat-free mass index
Gastrointestinal cancer
Prognosis
Content Type
Journal Article
Description
Background & Aims: The European Society for Clinical Nutrition and Metabolism (ESPEN) proposed the ESPEN diagnostic criteria (EDC) for malnutrition in 2015. There is no report on the association between the EDC and prognosis in patients with gastrointestinal (GI) and hepatobiliary–pancreatic (HBP) cancer. This study aimed to (1) determine the prevalence of EDC malnutrition, (2) investigate the validity of the EDC as a nutritional and prognostic indicator, and (3) examine which components of the EDC are most related to long-term prognosis in patients with GI and HBP cancers.
Methods: A total of 634 patients with primary GI and HBP cancers who underwent their first resection surgery between July 2014 and March 2018 were retrospectively recruited. According to the EDC, patients were divided into malnourished and non-malnourished groups. Clinical parameters and survival between these two groups were compared. The prognostic effects of the EDC and the EDC components were analyzed using Cox proportional hazard models.
Results: The prevalence of EDC malnutrition was 22%. Anthropometric data and biochemical data were associated with EDC malnutrition. The 5-year survival rate was lower in the malnourished group (72%) than in the non-malnourished group (73%; P = 0.007). The multivariate analysis demonstrated that the malnourished group was an independent risk factor for mortality (hazard ratio = 1.70 in the malnourished group; 95% confidence interval 1.08–2.63; P = 0.024). Among EDC components, body mass index (BMI) of <18.5 kg/m2 was an independent poor prognostic factor.
Conclusions: EDC malnutrition is associated with poor postoperative long-term prognosis. Among the EDC components, BMI of <18.5 kg/m2 is most associated with prognosis in patients with preoperative GI and HBP cancers.
Journal Title
Clinical Nutrition ESPEN
ISSN
24054577
Publisher
Elsevier|European Society for Clinical Nutrition and Metabolism
Volume
42
Start Page
265
End Page
271
Published Date
2021-02-11
Remark
論文本文は2022-02-11以降公開予定
Rights
© 2021. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
language
eng
TextVersion
その他
departments
Medical Sciences
University Hospital