Choroidal Changes After Coffee Intake
Nagasato, Daisuke Saneikai Tsukazaki Hospital|Tokushima University|Hiroshima University
Mitamura, Yoshinori Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Egawa, Mariko Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Murao, Fumiko Tokushima University Tokushima University Educator and Researcher Directory
Nagasawa, Toshihiko Saneikai Tsukazaki Hospital|Tokushima University
Komori, Natsumi Saneikai Tsukazaki Hospital
Sonoda, Shozo Kagoshima University
Sakamoto, Taiji Kagoshima University
Tabuchi, Hitoshi Saneikai Tsukazaki Hospital|Tokushima University|Hiroshima University
PURPOSE. The effects of coffee intake on the ratio of stromal and luminal components in the choroid and the underlying mechanism remain unclear. This prospective cross-sectional study aimed to explore how coffee intake affects the choroidal component ratio and circulation.
METHODS. Forty-nine right eyes of healthy adult volunteers were evaluated as the coffee intake group. Thirty-two right eyes of healthy volunteers served as the control group. The participants consumed 185 mL of coffee or water, respectively, and the systemic hemodynamics, enhanced-depth imaging optical coherence tomographic (EDI-OCT) images, and foveal mean blur rate (MBR), an indicator of blood flow velocity, were recorded at baseline and after coffee or water intake. The EDI-OCT images were binarized using ImageJ software, and subfoveal choroidal thickness (SCT) and whole, luminal, and stromal choroidal areas were calculated.
RESULTS. In the coffee intake group, significant decreases in SCT and luminal area peaked at 60 minutes after intake (both P < 0.001), whereas a significant increase in MBR peaked at 30 minutes (P < 0.001). No significant stromal area fluctuations were observed. SCT and luminal area fluctuations exhibited a significant positive correlation (r = 0.978, P < 0.001). Significant negative correlations of luminal area fluctuations with MBR fluctuations were observed by stepwise regression analysis (r = –0.220, P < 0.001). The control group exhibited no significant fluctuations.
CONCLUSIONS. Coffee-induced choroidal thinning may result mainly from a reduction in the choroidal vessel lumen, and this vessel lumen reduction correlated with an increased choroidal blood flow velocity after coffee intake. These coffee-induced changes in choroidal component ratio and circulation should be considered when evaluating choroids.
Investigative Ophthalmology & Visual Science
Silverchair|The Association for Research in Vision and Ophthalmology
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/).
|DOI (Published Version)|
|URL ( Publisher's Version )|
iovs_62_3_27.pdf 1.31 MB