| ID | 118732 |
| Title Alternative | sdLDL-C and Cardiovascular Events
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| Author |
Yamaji, Takayuki
Hiroshima University
Harada, Takahiro
Hiroshima University
Kajikawa, Masato
Hiroshima University
Maruhashi, Tatsuya
Hiroshima University
Kishimoto, Shinji
Hiroshima University
Mohamad Yusoff, Farina
Hiroshima University
Chayama, Kazuaki
Hiroshima University
Goto, Chikara
Hiroshima International University
Nakashima, Ayumu
Hiroshima University
Tomiyama, Hirofumi
Tokyo Medical University
Takase, Bonpei
National Defense Medical College Research Institute
Kohro, Takahide
Jichi Medical University
Suzuki, Toru
University of Leicester
Ishizu, Tomoko
University of Tsukuba
Ueda, Shinichiro
University of the Ryukyu
Yamazaki, Tsutomu
The University of Tokyo
Furumoto, Tomoo
Hokkaido University
Kario, Kazuomi
Jichi Medical University
Inoue, Teruo
Dokkyo Medical University
Watanabe, Kentaro
Yamagata University
Takemoto, Yasuhiko
Osaka Metropolitan University
Hano, Takuzo
Wakayama Medical University
Sata, Masataka
The University of Tokushima
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Ishibashi, Yutaka
Shimane University
Node, Koichi
Saga University
Maemura, Koji
Nagasaki University
Ohya, Yusuke
University of the Ryukyus
Furukawa, Taiji
Teikyo University
Ito, Hiroshi
Okayama University
Yamashina, Akira
Tokyo Medical University
Koba, Shinji
Showa University
Higashi, Yukihito
Hiroshima University
|
| Keywords | Small dense low-density lipoprotein cholesterol
Triglycerides
Type 2 diabetes mellitus
Statin
Cardiovascular events
|
| Content Type |
Journal Article
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| Description | Aim: There is little information on the relationships of serum small dense low-density lipoprotein cholesterol (sdLDL-C) levels and serum triglyceride (TG) levels with cardiovascular events in patients with coronary artery disease (CAD) and type 2 diabetes mellitus (DM) who are receiving statins. The aim of this study was to evaluate the relationships of serum TG levels and sdLDL-C levels as residual risks for cardiovascular events in patients with CAD and type 2 DM who were being treated with statins.
Methods: The subjects were divided into four groups based on TG levels and sdLDL-C levels: sdLDL-C of ＜40.0 mg/dL and TG of ＜150 mg/dL, sdLDL-C of ≥ 40.0 mg/dL and TG of ＜150 mg/dL, sdLDL-C of ＜40.0 mg/dL and TG of ≥ 150 mg/dL, and sdLDL-C of ≥ 40.0 mg/dL and TG of ≥ 150 mg/dL. During a median follow-up period of 1419 days, cardiovascular events occurred in 34 patients. Results: The incidences of cardiovascular events were significantly higher in patients with sdLDL-C of ≥ 40.0 mg/dL and TG of ＜150 mg/dL and in patients with sdLDL-C of ≥ 40.0 mg/dL and TG of ≥ 150 mg/dL, but not in patients with sdLDL-C of ＜40.0 mg/dL and TG of ≥ 150 mg/dL, than in patients with sdLDL-C of ＜40.0 mg/dL and TG of ＜150 mg/dL. Conclusions: Under the condition of treatment with statins, patients with CAD and type 2 DM who had sdLDL-C levels of ≥ 40.0 mg/dL had a high risk for cardiovascular events even though serum TG levels were controlled at ＜150 mg/dL. |
| Journal Title |
Journal of Atherosclerosis and Thrombosis
|
| ISSN | 18803873
13403478
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| Publisher | Japan Atherosclerosis Society
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| Volume | 31
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| Issue | 4
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| Start Page | 478
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| End Page | 500
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| Published Date | 2024-04-01
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| Rights | This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License (https://creativecommons.org/licenses/by-nc-sa/4.0/).
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| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
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| TextVersion |
Publisher
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| departments |
Medical Sciences
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