ID | 119469 |
Author |
Neriya, Yutaro
Utsunomiya University
Kojima, Shohei
RIKEN
Sakiyama, Arata
Osaka City University
Kishimoto, Mai
Hokkaido University
Iketani, Takao
Tokyo University of Agriculture and Technology
Watanabe, Tadashi
University of the Ryukyus
Abe, Yuichi
Aichi Cancer Center
Shimoda, Hiroshi
Yamaguchi University
Nakagawa, Keisuke
Gifu University
Koma, Takaaki
Tokushima University
Tokushima University Educator and Researcher Directory
KAKEN Search Researchers
Matsumoto, Yusuke
Tokyo Metropolitan Institute of Medical Science
|
Content Type |
Journal Article
|
Description | Members of the order Bunyavirales infect a wide variety of host species, including plants, animals and humans, and pose a threat to public health. Major families in this order have tri-segmented negative-sense RNA genomes, the 5′ and 3′ ends of which form complementary strands that serve as a replication promoter. Elucidation of the mechanisms by which viral polymerases recognize the promoter to initiate RNA synthesis is important for understanding viral replication and pathogenesis, and developing antivirals. A list of replication promoter configuration patterns may provide details on the differences in the replication mechanisms among bunyaviruses. By using public sequence data of all known bunyavirus species, we constructed a comprehensive list of the replication promoters comprising 40 nucleotides in both the 5′ and 3′ ends of the genome that form a specific complementary strand. Among tri-segmented bunyaviruses, members of the family Nairoviridae, including the highly pathogenic Crimean-Congo hemorrhagic fever virus, have evolved a GC-rich promoter structure differing from that of other families. The unique promoter structure might be related to the large genome size of the family Nairoviridae among bunyaviruses, and the large genome architecture might confer pathogenic advantages. The promoter list provided in this report is useful for predicting the virus family-specific replication mechanisms of bunyaviruses.
|
Journal Title |
Scientific Reports
|
ISSN | 20452322
|
Publisher | Springer Nature
|
Volume | 12
|
Start Page | 13560
|
Published Date | 2022-08-09
|
Rights | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
|
EDB ID | |
DOI (Published Version) | |
URL ( Publisher's Version ) | |
FullText File | |
language |
eng
|
TextVersion |
Publisher
|
departments |
Medical Sciences
|