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ID 119486
Title Alternative
尿中タイチンの上昇は、急性期脳卒中の転帰と関連する
Author
Nakanishi, Nobuto Tokushima University
Hara, Kanako Tokushima University
Machida, Kyoka Tokushima University
Keywords
Stroke
Titin
Muscle atrophy
Biomarker
Prognosis
urinary titin
acute stroke
nutrition
rehabilitation
Content Type
Thesis or Dissertation
Description
Introduction: Urinary titin is a biomarker of muscle atrophy, which is a serious complication after stroke. However, there are currently no clinical data regarding urinary titin in stroke patients. Methods: Consecutive stroke patients admitted to the stroke care unit were included. Spot urine samples were collected immediately after admission, and on days 3, 5, and 7. The primary outcome was the trend of urinary titin in patients after acute stroke. The secondary outcomes included the association between the peak urinary titin level and the modified Rankin Scale (mRS) score, the National Institutes of Health Stroke Scale (NIHSS) score, and the Barthel index (BI) upon hospital discharge. Multivariate analysis was adjusted for age, sex, NIHSS at admission, and the peak urinary titin to predict poor outcome (mRS 3–6). Results: Forty-one patients were included (29 male; age, 68±15 years), 29 had ischemic stroke, 8 had intracerebral hemorrhage, and 4 had subarachnoid hemorrhage. The levels of urinary titin on days 1, 3, 5, and 7 were 9.9 (4.7–21.1), 16.2 (8.6–22.0), 8.9 (4.8–15.2), and 8.7 (3.6–16.2) pmol/mg Cr, respectively. The peak urinary titin level was associated with the mRS score (r = 0.55, p < 0.01), the NIHSS score (r = 0.72, p < 0.01), and the BI (r = –0.59, p < 0.01) upon hospital discharge. In multivariate analysis, the peak urinary titin was associated with poor outcome (p = 0.03). Conclusions: Urinary titin rapidly increased after stroke and was associated with impaired functional outcomes at hospital discharge.
Journal Title
Journal of Stroke and Cerebrovascular Diseases
ISSN
10523057
15328511
NCID
AA11543284
Publisher
Elsevier
Volume
30
Issue
3
Start Page
105561
Published Date
2020-12-24
Remark
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Manabu Ishiharaの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3836号
Diploma Number
甲医第1613号
Granted Date
2024-06-27
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences