ID | 255 |
Title Transcription | Hypoxia-inducible factor-1 : ソノ ハツゲン セイギョ オヨビ コウクウ ヘンペイ ジョウヒガン ニオケル カカワリ
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Title Alternative | Hypoxia-Inducible Factor-1 : its Regulation and Role in Oral Cancer
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Author |
Yamamoto, Tetsuya
Department of Oral Oncology, Program of Tumor Biology and Regulation, Kochi Medical School, Kochi University
Tokushima University Educator and Researcher Directory
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Keywords | 低酸素
Hypoxia-inducible factor-1
口腔扁平上皮癌
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Content Type |
Departmental Bulletin Paper
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Description | Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor that controls the hypoxic response of mammalian cells. HIF-1 plays crucial roles by regulating the transcription of the target genes, which are involved in energy metabolism, angiogenesis, cell proliferation/apoptosis, cell invasion/metastasis, drug resistance. The regulation of HIF-1 involves a variety of mechanism including transcription, translation, post-translational modification, protein-protein interaction and degradation. In tumor cells, HIF-1 is present at high due to hypoxic conditions, the activation of oncogenes or the inactivation of tumor suppressor genes and HIF-1 levels are associated with aggressive progression, diminished therapeutic response and poor prognosis. We have shown that HIF-1 prevents apoptotic cell death of oral squamous cell carcinoma (OSCC) cells and that the enhanced expression of HIF-1 in OSCC cells is associated with resistance against chemotherapeutic drugs and γ-rays. Therefore, the inhibition of HIF-1 activity is a strategy for treatment of cancer. HIF-1-targeting anticancer would improve the prognosis of many cancers including oral cancer.
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Journal Title |
四国歯学会雑誌
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ISSN | 09146091
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NCID | AN10050046
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Volume | 18
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Issue | 2
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Start Page | 221
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End Page | 233
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Sort Key | 221
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Published Date | 2006-01
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Remark | 公開日:2010年1月24日で登録したコンテンツは、国立情報学研究所において電子化したものです。
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FullText File | |
language |
jpn
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departments |
Integrated Arts and Sciences
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Report Type | 総説
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