ID 255
Title Transcription
Hypoxia-inducible factor-1 : ソノ ハツゲン セイギョ オヨビ コウクウ ヘンペイ ジョウヒガン ニオケル カカワリ
Title Alternative
Hypoxia-Inducible Factor-1 : its Regulation and Role in Oral Cancer
Author
Yamamoto, Tetsuya Department of Oral Oncology, Program of Tumor Biology and Regulation, Kochi Medical School, Kochi University Tokushima University Educator and Researcher Directory
Keywords
低酸素
Hypoxia-inducible factor-1
口腔扁平上皮癌
Content Type
Departmental Bulletin Paper
Description
Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor that controls the hypoxic response of mammalian cells. HIF-1 plays crucial roles by regulating the transcription of the target genes, which are involved in energy metabolism, angiogenesis, cell proliferation/apoptosis, cell invasion/metastasis, drug resistance. The regulation of HIF-1 involves a variety of mechanism including transcription, translation, post-translational modification, protein-protein interaction and degradation. In tumor cells, HIF-1 is present at high due to hypoxic conditions, the activation of oncogenes or the inactivation of tumor suppressor genes and HIF-1 levels are associated with aggressive progression, diminished therapeutic response and poor prognosis. We have shown that HIF-1 prevents apoptotic cell death of oral squamous cell carcinoma (OSCC) cells and that the enhanced expression of HIF-1 in OSCC cells is associated with resistance against chemotherapeutic drugs and γ-rays. Therefore, the inhibition of HIF-1 activity is a strategy for treatment of cancer. HIF-1-targeting anticancer would improve the prognosis of many cancers including oral cancer.
Journal Title
四国歯学会雑誌
ISSN
09146091
NCID
AN10050046
Volume
18
Issue
2
Start Page
221
End Page
233
Sort Key
221
Published Date
2006-01
Remark
公開日:2010年1月24日で登録したコンテンツは、国立情報学研究所において電子化したものです。
FullText File
language
jpn
departments
Integrated Arts and Sciences
Report Type
総説