ID 25678
Author
Tran, Yen Hai Division of Clinical Otology, The University of Tokushima School of Medicine
Ohsaki, Katsuichiro Division of Clinical Otology, The University of Tokushima School of Medicine
Ii, Kunio First Department of Pathology, The University of Tokushima School of Medicine
Ye, Qing Department of Otolaryngology, Fujian Provincial Hospital
Yokozeki, Masahiko Department of Orthodontics, The University of Tokushima School of Dentistry
Moriyama, Keiji Department of Orthodontics, The University of Tokushima School of Dentistry
Keywords
hydroxyapatite
auditory bulla bone
implant
biocompatibility
rats
Content Type
Journal Article
Description
To investigate the biocompatibility of a synthetic auditory ossicle to host bone, small thin Apaceram® disks composed of dense hydroxyapatite were implanted under the periosteum of the left auditory bulla in 32 rats for periods ranging from 1 day to 270days. A sham operation performed on 10 rats served as a control. Decalcified histological sections stained with hematoxylin and eosin were observed using light microscopy. The experiment showed:1) a time-dependent mature fibrous connective tissue surrounding the Apaceram® disk, 2) no evidence of inflammatory reaction caused by the implant from 90 days after implantation until the end of the experiment, 3) no evidence of osteolysis by osteoclasts caused by the implant, and 4) direct contact of bone to the implant on the bone-disk interface at 180 and 270 days after implantation. The findings suggest that Apaceram® has a high degree of implant biocompatibility, making it a satisfactory substitute biomaterial for otological reconstructive surgeries.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
47
Issue
1-2
Start Page
56
End Page
60
Sort Key
56
Published Date
2000
Remark
EDB ID
FullText File
language
eng