ID 284
Title Transcription
コウクウガン ノ メンエキ リョウホウ : キソ カラ リンショウ エ : レンサ キュウキン Toll-like receptor ジュジョウ サイボウ
Title Alternative
Immunotherapy for Oral Cancer:Bench to Bed : Streptococcus, Toll-like Receptor, Dendritic Cell
Author
Okamoto, Masato Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University
Keywords
癌免疫療法
OK-432
リポタイコ酸関連分子
Toll-like receptor 4シグナル
樹状細胞
Content Type
Departmental Bulletin Paper
Description
OK-432, a penicillin-killed and lyophilized preparation of a low-virulence strain (Su) of Streptococcus pyogenes (group A), is successfully used as an immunotherapeutic agent in many types of malignancies including head and neck cancer. Recently, we succeeded in isolating the effective molecule (lipoteichoic acid-related molecule OK-PSA) by affinity chromatography of a butanol extract of OK-432 on CNBr-activated sepharose 4B bound TS-2 monoclonal antibody that neutralizes interferon-γ-inducing activity of OK-432. In this review, we described the findings regarding the effect of the OK-432 and OK-PSA in enhancing anti-tumor immunity and the molecular mechanism. Our in vitro and in vivo study demonstrated that OK-PSA induces Th1-type cytokines in human as well as in mice, and elicits anti-tumor effect in tumor-bearing mice. Furthermore, our data indicated that the signaling mediated by Toll-like receptor (TLR) 4/MD-2 was involved in regulating OK-432/OK-PSA-induced anti-tumor immunity. It is suggested that OK-PSA is most responsible molecule for the antitumor effect of OK-432, that TLR4 and MD-2 are certain molecular targets for OK-432 as well as OK-PSA, and that expression of these genes may be useful marker to discriminate between responder and nonresponder to OK-432-based immunotherapy. In addition, OK-432/OK-PSA induced tumor-antigen specific cytotoxic T cells via the maturation of dendritic cells (DCs) which are professional antigenpresenting cells. It has been strongly suggested the possibility that OK-432/OK-PSA may be a useful adjuvant for DC therapy.
Journal Title
四国歯学会雑誌
ISSN
09146091
NCID
AN10050046
Volume
19
Issue
2
Start Page
151
End Page
162
Sort Key
151
Published Date
2007-01
Remark
公開日:2010年1月24日で登録したコンテンツは、国立情報学研究所において電子化したものです。
FullText File
language
jpn
Report Type
総説