ID 45889
Title Transcription
スイミン ト セイタイ リズム ノ サイシン ノ チケン
Title Alternative
Update on Research for Sleep and Circadian Rhythm
Author
Sei, Hiroyoshi Department of Integrative Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
sleep
slow wave activity
learning
circadian
clock genes
Content Type
Journal Article
Description
Slow wave activity (SWA:<4Hz) in electroencephalograms (EEG) appears during non-REM sleep, which is regulated homeostatically, increasing after wakefulness and returning to baseline during sleep. Recently, it has been suggested that SWA homeostasis may reflect synaptic changes underlying a cellular need for sleep. Huber et al. (Nature,430 (6995) :78‐81,2004) have shown that SWA homeostasis has a local component, which can be triggered by a learning task involving specific brain regions. We also found an impaired SWA rebound after sleep deprivation in fmr1 (fragile-X syndrome mental retardation1) knockout mice, indicating an involvement of fmr1gene in neural plasticity.
Clock genes regulating circadian rhythm are recently thought to modulate several brain functions. Spanagel et al. (Nature Medicine,11 (1) :35‐42,2004) have shown that per2mutant mice show alterations in the glutamatergic system in the brain, accompanied by increasing alcohol intake. They also found that, in humans, genetic variations of human per 2 are related to the alcohol consumption Furthermore, clock genes have been indicated to have important roles in not only brain but also peripheral organs.
In future, we need an animal model for“insomnia”which is one of the most common sleep disorders in humans.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
61
Issue
1-2
Start Page
2
End Page
6
Sort Key
2
Published Date
2005-04-25
Remark
EDB ID
FullText File
language
jpn
departments
Medical Sciences