ID 49311
Title Transcription
マッショウ タンカクキュウ サイボウ オ モチイタ マッショウ ドウミャク ヘイソクショウ ニ タイスル アラタナ ケッカン シンセイ リョウホウ ノ ココロミ
Title Alternative
Peripheral blood-derived mononuclear cell implantation for therapeutic angiogenesis in patients with peripheral arterial disease
Author
Iwase, Takashi Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School KAKEN Search Researchers
Kurobe, Hirotsugu Department of Cardiovascular Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Yagi, Shusuke Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Hara, Tomoko Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School
Choraku, Masahito Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School
Fujimura, Mitsunori Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School
Ozaki, Shuji Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School
Akaike, Masashi Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Abe, Masahiro Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Masuda, Yutaka Department of Cardiovascular Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School
Azuma, Hiroyuki Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School
Matsumoto, Toshio Department of Medicine and Bioregulatory Sciences, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kitagawa, Tetsuya Department of Cardiovascular Surgery, Institute of Health Biosciences, The University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
peripheral arterial disease
mononuclear cell
cell therapy
therapeutic angiogenesis
Content Type
Journal Article
Description
Earlier studies have shown that bone marrow-derived mononuclear cell(BM-MNC)implantation induces therapeutic angiogenesis in patients with peripheral arterial disease(PAD). However, the invasiveness of bone marrow collection limits clinical application of BM-MNC implantation.We performed peripheral blood-derived mononuclear cell(PB-MNC)implantation in ischemic limbs of five patients with PAD. After implantation, clinical symptoms such as rest pain and numbness were relieved in four patients. Maximal walking distance markedly increased from 160 m to 915 m in one patient. Non-healing ulcers were cured after repeated cell implantation in one patient with Burger disease. There was no adverse event. These findings suggest that PB-MNC implantation is a safe and noninvasive strategy for therapeutic angiogenesis for the treatment of severe PAD.
Journal Title
四国医学雑誌
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
62
Issue
3-4
Start Page
137
End Page
141
Sort Key
137
Published Date
2006-08-25
Remark
EDB ID
FullText File
language
jpn
departments
Medical Sciences
Institute of Advanced Medical Sciences
University Hospital