ID 59702
Title Transcription
イソプレン ソクサ オ ユウスル ショクブツ セイブン ノ ex vivo ユウキ ゴウセイ ト ソノ セイリ カッセイ ノ ヒョウカ
Title Alternative
Design, ex vivo Synthesis, and Biological Activities of Plant Constituents Containing an Isoprene Side-chain Based on Isoprenomics
Author
Uto, Yoshihiro Division of Bioinformatics Engineering, Department of Life System, Institute of Technology and Science, Graduate School of The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Koyama, Daisuke Graduate School of Advanced Technology and Science, The University of Tokushima
Otomo, Naoki Graduate School of Advanced Technology and Science, The University of Tokushima
Abe, Chiaki Graduate School of Advanced Technology and Science, The University of Tokushima
Shirai, Tadashi Graduate School of Advanced Technology and Science, The University of Tokushima
Nakata, Eiji Division of Bioinformatics Engineering, Department of Life System, Institute of Technology and Science, Graduate School of The University of Tokushima
Hori, Hitoshi Division of Bioinformatics Engineering, Department of Life System, Institute of Technology and Science, Graduate School of The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
Antioxidant
Acyclic tocopherol
Antiatherosclerosis drug
phytyl quinol
Chick embryo chorioallantoic membrane
Isoprenomics
Content Type
Departmental Bulletin Paper
Description
Phytyl quinols, namely acyclic tocopherols, are key intermediates of tocopherol biosynthesis,
but their biological activities remain unclear. We therefore investigated the structure-activity
relationship of phytyl quinols to apply a chemical biosynthesis design for an antiatherosclerosis
drug based on isoprenomics. We have achieved the biosynthesis-oriented synthesis of α- and
β-phytyl quinol as an unnatural intermediate, other γ- and δ-phytyl quinol as a natural one. All four
phytyl quinols showed almost the same moderate inhibitory activity against low-density lipoprotein
oxidation instead of their different degree of C-methylation with character different from
tocopherols. In vivo toxicities of phytyl quinols against chick embryo chorioallantoic membrane
vasculature were hardly observed. We proposed phytyl quinols were possible antioxidants in plants
and animals, like vitamin E.
Journal Title
徳島大学大学院ソシオテクノサイエンス研究部研究報告
ISSN
21859094
NCID
AA12214889
Publisher
徳島大学大学院ソシオテクノサイエンス研究部
Volume
53
Start Page
52
End Page
56
Sort Key
52
Published Date
2008-05-30
EDB ID
FullText File
language
jpn
departments
Bioscience and Bioindustry