ID 72667
Author
Fukuhara, Yayoi Department of Pharmacology, Institute of Health Bioscience, the University of Tokushima Graduate School
Tsuchiya, Koichiro Department of Medical Pharmacology, Institute of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Horinouchi, Yuya Department of Pharmacology, Institute of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory
Tajima, Soichiro Department of Pharmacology, Institute of Health Bioscience, the University of Tokushima Graduate School
Kihira, Yoshitaka Department of Pharmacology, Institute of Health Bioscience, the University of Tokushima Graduate School
Hamano, Shuichi Department of Pathological Science and Technology, Institute of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kawazoe, Kazuyoshi Department of Pharmacy, Tokushima University Hospital KAKEN Search Researchers
Ikeda, Yasumasa Department of Pharmacology, Institute of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Ishizawa, Keisuke Department of Pharmacology, Institute of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Tomita, Shuhei Department of Pharmacology, Institute of Health Bioscience, the University of Tokushima Graduate School
Tamaki, Toshiaki Department of Pharmacology, Institute of Health Bioscience, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
nifedipine
nitrosonifedipine
antioxidant
tumor necrosis factor-α
reactive oxygen species
endothelial cells
cumene hydroperoxide
Content Type
Journal Article
Description
Recently, increasing evidence suggests that the antihypertensive drug nifedipine acts as a protective agent for endothelial cells, and that the activity is unrelated to its calcium channel blocking. Nitrosonifedipine (NO-NIF) is metabolically and photochemically produced from nifedipine, and NO-NIF has been recognized as a contaminant of nifedipine because it has no antihypertensive effect. Treatment of tumor necrosis factor-α (TNF-α) suppressed the cell viability and facilitated the expression of Inter-Cellular Adhesion Molecule 1(ICAM-1) in human glomerular endothelial cells (HGECs) though, pretreatment of NO-NIF significantly recovered the TNF-α-induced cell damage to the same extent as Trolox-C did, and suppressed the ICAM-1 expression in a concentration dependent manner. In addition, NO-NIF inhibited the cell toxicity induced by cumene hydroperoxide, which hampers the integrity of cell membrane through oxidative stress, as effective as Trolox-c. These data suggest that NO-NIF is a candidate for a new class of antioxidative drug that protect cells against oxidative stress in glomerular endothelial cells.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
58
Issue
1-2
Start Page
118
End Page
126
Sort Key
118
Published Date
2011-02
Remark
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
FullText File
language
eng
departments
Pharmaceutical Sciences
Medical Sciences