ID 72821
Author
Nagao, Tamiko Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School
Yamashita, Tomoki Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School
Miyake, Ariko Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Uchiyama, Tsuneo Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Nomaguchi, Masako Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Adachi, Akio Department of Microbiology, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
HIV-1
Vif
APOBEC3G
APOBEC3F
Content Type
Journal Article
Description
We examined a series of site-directed point mutants of human immunodeficiency virus type 1 (HIV-1) Vif for their interaction with cellular anti-viral factors APOBEC3G/APOBEC3F. Mutant viruses that display growth-defect in H9 cells did not counteract effectively APOBEC3G and/or APOBEC3F without exception, as monitored by single-cycle infectivity assays. While growth-defective mutants of Vif C-terminal region were unable to suppress APOBEC3G/APOBEC3F, some N-terminal region mutants did neutralize one of APOBEC3G/APOBEC3F. These data have suggested that members of APOBEC3 family other than APOBEC3G/APOBEC3F are not important for anti-HIV-1 activity. Furthermore, APOPEC3G/APOBEC3F were found to differently associate with Vif in virions as analyzed by equilibrium density centrifugation. Taken together, these results indicated that interaction of HIV-1 Vif and APOBEC3G is distinct from that between Vif and APOBEC3F.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
57
Issue
1-2
Start Page
89
End Page
94
Sort Key
89
Published Date
2010-02
Remark
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
FullText File
language
eng
departments
Medical Sciences