ID 74523
Title Alternative
ジェネティック制御下にある発育鶏卵を用いた工学的in vivo 薬剤評価系の開発
Author
Abe, Chiaki Graduate School of Advanced Technology and Science, The University of Tokushima
Uto, Yoshihiro Division of Bioinformatics Engineering,Department of Life System, Institute of Technology and Science,Graduate School of The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Nakata, Eiji Division of Bioinformatics Engineering,Department of Life System, Institute of Technology and Science,Graduate School of The University of Tokushima
Hori, Hitoshi Division of Bioinformatics Engineering,Department of Life System, Institute of Technology and Science,Graduate School of The University of Tokushima Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
Antioxidant
Artepillin C
Chick embryo chorioallantoic membrane
vascular injury
Content Type
Departmental Bulletin Paper
Description
The drug discovery research of clinical-use antioxidants, which may control various vascular
disorders caused by the oxidative stress, is extremely important. We present the development of an
in vivo evaluation system of antioxidants for their vascular protective activities using the chick
embryonic chorioallantoic membrane (CAM). In the case of 12-days chick embryos, the topical
administration of 2,2'-azobis(2-methylpropionamidine) dihydrochloride (AAPH) induced their
vascular injuries against the CAM veins and venous capillaries but without substantial fatal damage.
Artepillin C, a potent natural antioxidant, did not show the chick embryo’s venous injury, and
pre-treatment with artepillin C would tend to protect the CAM veins injuries induced by the
post-administration of AAPH. These results suggest that artepillin C might be able to protect the
AAPH-induced vascular injury in in vivo. In conclusion, we showed the possibility of in vivo
evaluation system of antioxidants for their vascular protective activities using the chick embryo.
Journal Title
徳島大学大学院ソシオテクノサイエンス研究部研究報告
ISSN
21859094
NCID
AA12214889
Volume
54
Start Page
70
End Page
74
Sort Key
70
Published Date
2009
FullText File
language
eng
departments
Bioscience and Bioindustry