ID 75865
Author
Ali, Abdellah Hamed Khalil Department of Respiratory Medicine, Sohag Faculty of Medicine, Sohag University|Department of Oncological Medical Services, Institute of Health Biosciences, the University of Tokushima Graduate School
Takizawa, Hiromitsu Department of Thoracic, Endocrine and Oncological Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Kondo, Kazuya Department of Oncological Medical Services, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Nakagawa, Yasushi Department of Thoracic, Endocrine and Oncological Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School
Toba, Hiroaki Department of Thoracic, Endocrine and Oncological Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Khasag, Narmisheekh Department of Thoracic, Endocrine and Oncological Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School
Kenzaki, Koichiro Department of Thoracic, Endocrine and Oncological Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School
Sakiyama, Shoji Department of Thoracic, Endocrine and Oncological Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School
Mohammadien, Hamdy Ali Department of Respiratory Medicine, Sohag Faculty of Medicine, Sohag University
Mokhtar, Essam Ahmed Department of Cardiothoracic Surgery, Sohag Faculty of Medicine, Sohag University
Tangoku, Akira Department of Thoracic, Endocrine and Oncological Surgery, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
lung cancer
photodynamic therapy
fluorescence bronchoscopy
Content Type
Journal Article
Description
Purpose : To evaluate the accuracy of fluorescence bronchoscopy by precise histological analysis of the photodynamic therapy (PDT) treated lesions. Methods : A retrospective study was conducted on thirteen patients (16 lesions) with centrally located early lung cancer (CLELC) had been undergone photodynamic therapy and had been followed up by fluorescence bronchoscopy. Fluorescence bronchoscopy was performed between 1 and 60 months after photodynamic therapy. Results : Of the 16 early carcinomas treated, 14 (87.5%) had a CR, 2 (12.5%) had a NR after initial PDT. Among the 14 carcinomas achieving a CR, 4 (29%) recurred locally from 6 to 12 months after initial PDT. A total of 62 surveillance auto fluorescence bronchoscopies (average ; 4.5/patient) and 47 biopsies (average ; 4/patient) were performed after PDT. The addition of the SAFE-3000 examination to conventional bronchoscopy increased the sensitivity of screening from 69% to 100%, which yielded a relative sensitivity of 145% with a negative predictive value of 100%. Out of 14 CR lesions, 9 lesions finally reverted to normal fluorescence. CR cases that did not show normal fluorescence were relapsed cases or a patient with complete response whose treated lesion showed fibrosis in the sub mucosa. Histopathological finding of the complete response sites which demonstrated temporal fluorescent defect consisted of inflammatory lesions, goblet cell hyperplasia, basal cell hyperplasia, squamous metaplasia or dysplasia. Conclusion : our results confirm that SAFE-3000 allows accurate assessment of the quality and efficacy of PDT.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
58
Issue
1-2
Start Page
46
End Page
55
Sort Key
46
Published Date
2011-02
Remark
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
FullText File
language
eng
departments
Medical Sciences