ID 78648
Author
Sakaki, Manabu Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduated School|Department of Urology, Kamei Hospital
Fukumori, Tomoharu Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduated School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Fukawa, Tomoya Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduated School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Elsamman, Essam Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduated School
Shiirevnyamba, Avirmed Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduated School
Nakatsuji, Hiroyoshi Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduated School
Kanayama, Hiro-omi Department of Urology, Institute of Health Biosciences, the University of Tokushima Graduated School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
clear cell renal cell carcinoma
galectin-3
prognosis
Content Type
Journal Article
Description
Overexpression of galectin-3 in a variety of cancer cell lines has been shown
to correlate with tumor progression and metastasis. In this study, we investigated the
expression of galectin-3 in clear cell renal cell carcinoma (CC-RCC) and evaluated the
relationship between galectin-3 expression levels and the clinicopathological features
of CC-RCC. Expression of galectin-3 in the kidney cancer cell lines Caki-1, Caki-2, A704,
ACHN and KPK-1 were evaluated using western blot analysis, while galectin-3 expression
in CC-RCC tissues and normal parenchyma were measured by real-time PCR and
immunohistochemistry. We found that galectin-3 was overexpressed in the Caki-1, Caki-
2, A704, ACHN and KPK-1 cell lines and that the expression level in CC-RCC was also
significantly higher than that in renal parenchyma obtained from the same patient samples
(p=0.039). Galectin-3 expression in CC-RCC with distant metastasis was also significantly
higher than that in CC-RCC without distant metastasis (p=0.045). In conclusion,
we revealed that galectin-3 is highly expressed in CC-RCC, especially in CC-RCC
with distant metastasis, suggesting that galectin-3 may serve as a novel target molecule
for predicting CC-RCC metastasis.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
57
Issue
1-2
Start Page
152
End Page
157
Sort Key
152
Published Date
2010-02
Remark
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
FullText File
language
eng
departments
University Hospital
Medical Sciences