ID 79137
Author
Teshigawara, Kiyoshi Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School|Division of Biofunctional Evaluation Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama
Hosaka, Toshio Department of Public Health and Applied Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
Yamaguchi, Miwa Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Terada, Eri Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
Kisyuku, Yuka Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
Fukunaga, Keiko Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
Hirata, Yohko Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
Jambaldorj, Bayasgalan Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
Harada, Nagakatsu Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Sakai, Tohru Department of Public Health and Applied Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Nakaya, Yutaka Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
HBA
hyperlipidemia
TNFα
MCP1
Content Type
Journal Article
Description
Hyperbaric air (HBA) is used to improve healing of wounds including diabetic
ulcer. The aim of this study was to clarify the effects of HBA exposure on lipid and glucose
metabolism in db/db mice. HBA did not influence the weight of db/db mice. Serum
levels of free fatty acid and triglyceride, but not glucose and insulin, were significantly
decreased after 6 weeks of treatment with HBA. The mRNA expressions of CPT-1, PPARα
and PGC-1α genes, which are related to lipid metabolism, were significantly up-regulated
in the muscle and liver. Increases in TNFα and MCP1 mRNA, which impaired lipid metabolism,
were also attenuated by HBA treatment. These results suggest that exposure
of HBA could have beneficial effects on lipid metabolism in patients with type 2 diabetes
mellitus.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
57
Issue
3-4
Start Page
224
End Page
231
Sort Key
224
Published Date
2010-08
Remark
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
departments
Medical Sciences