ID 79153
Author
Shiota, Asuka Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
Hada, Takahiko Hada Giken, Co Ltd.
Baba, Tomoko Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
Sato, Minako Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
Yamanaka-Okumura, Hisami Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Yamamoto, Hironori Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Taketani, Yutaka Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Takeda, Eiji Department of Clinical Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
glycoglycerolipid
5-Fluorouracil
mucositis
oxidative stress
Content Type
Journal Article
Description
Glycoglycerolipids are mostly found in plants, however the beneficial effects of
the glycoglycerolipids on mammalian body have not been understood. In this study, we
investigated the effects of glycolipid extracts from spinach, which highly contained glycoglycerolipids,
on mucosal injury induced by 5-fluorouracil (5-FU) in rats. Preadministration
of glycolipid extracts from spinach (20 mg/kg body weight) prevented villous atrophy,
misaligned crypts, and increased inflammatory cytokines in rat jejunum treated
with 5-FU (300 mg/kg body weight) compared with the extracts from soybean. The glycolipid
extracts from spinach highly contained monogalactosyl-diacylglycerol (MGDG)
and diglactosyl-diacylglycerol (DGDG). In Caco-2 cells, MGDG and DGDG inhibited the
production of reactive oxygen species induced by phorbol ester. We concluded that glycolipid
extracts from spinach has anti-oxidative and anti-inflammatory effects, and the
extract may be useful for prevention of drug-induced mucosal injury and other inflammatory
diseases.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
57
Issue
3-4
Start Page
314
End Page
320
Sort Key
314
Published Date
2010-08
Remark
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
FullText File
language
eng
departments
Medical Sciences