ID 79154
Author
Nishimura, Akiyoshi Department of Forensic Medicine, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
lectin
apoptosis
postmortem diagnosis for schizophrenia
dentate gyrus
spherical deposit
Content Type
Journal Article
Description
Previously, multi-lectin positive spherical shaped deposits were detected in the
hippocampal formation of degenerative demented and schizophrenic brains and reported
they possessed some possibility as a predominant tool of postmortem diagnosis, more detected
in schizophrenia cases than age-matched control cases. Multi-fluorescent immunohistochemical
and lectin histochemical method and immuno electron microscope
method were performed on 51 forensic autopsied brains containing 16 cases of schizophrenia.
In multi-fluorescent staining, partial disrupted nucleus with decreased staining
properties by mean of SYBR green were detected, and lectin and single strand DNA
were co-stained in the portion of partial disrupted nucleus. In immuno electron microscope
method, lectin positive structures were also detected in the portion of partial disrupted
nucleus. These neurons were suspected in the process of apoptosis by their distinguishable
features. Some experimental studies were reported that a kind of therapeutic
products of major tranquillizers induced neuron apoptosis in dentate gyrus. As the lectin
positive spherical shaped deposits were detected in not only 5 schizophrenia cases without
drug treatment but also in 11 schizophrenia cases with drug treatment in this study,
they might be detected as the intrinsic pathological change of schizophrenia. The lectin
positive spherical shaped deposits detected in the hippocampal formation were suspected
as the histopathological marker of the postmortem diagnosis for schizophrenia. Further
examination for specifying group of neurons detected them in and initiated apoptosis
are necessitated.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
57
Issue
3-4
Start Page
183
End Page
190
Sort Key
183
Published Date
2010-08
Remark
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
FullText File
language
eng
departments
Medical Sciences