ID 79178
Author
Tamagawa, Kazuhiko Department of Immunology and Parasitology, Institute of Health Biosciences, the University of Tokushima Graduate School|Tomita Pharmaceutical Co. Ltd.
Nakayama-Imaohji, Haruyuki Department of Immunology and Parasitology, Institute of Health Biosciences, the University of Tokushima Graduate School
Wakimoto, Shin Department of Immunology and Parasitology, Institute of Health Biosciences, the University of Tokushima Graduate School
Ichimura, Minoru Department of Immunology and Parasitology, Institute of Health Biosciences, the University of Tokushima Graduate School
Kuwahara, Tomomi Department of Immunology and Parasitology, Institute of Health Biosciences, the University of Tokushima Graduate School
Keywords
titanium oxide
inorganic phosphate
adsorbent
renal failure
Content Type
Journal Article
Description
Hyperphosphatemia adversely affects the prognosis of patients with chronic renal
failure (CRF). We synthesized a titanium oxide-like compound (TAP) as a phosphate
adsorbent for treatment of hyperphosphatemia in CFR patients. We evaluated the ability
of TAP to adsorb inorganic phosphate in vitro and in vivo. TAP was shown to contain
sulfate and hydroxyl groups by thermal analysis, which probably involved in phosphate
adsorption through an ionic exchange mechanism. TAP constantly adsorbed phosphate
(66.20-72.84 mg/g TAP) over a wide pH range (1.22-7.27) in vitro. To evaluate the phosphate
binding potential of TAP in vivo, adenine-induced CRF rats were fed AIN-76 diet
containing 3% TAP, 10% TAP, 3% sevelamer hydrochloride (clinical phosphate adsorbent),
or 3% calcium carbonate, and serum levels of phosphate and calcium and urinary phosphate
were compared with those in untreated CRF rats. Orally administered TAP showed
the inhibitory effect on serum phosphate level in adenine-induced CRF rats, which was
equivalent to that of sevelamer hydrochloride. These results indicate that TAP is a useful
alternative phosphate-binder with fewer side effects than sevelamer hydrochloride
and calcium carbonate.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
57
Issue
3-4
Start Page
275
End Page
283
Sort Key
275
Published Date
2010-08
Remark
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
FullText File
language
eng