ID 82891
Author
Takata, Shinjiro Division of Rehabilitation, Tokushima University Hospital
Yonezu, Hiroshi Department of Orthopedic Surgery, Mitoyo General Hospital
Sibata, Akira Faculty of Pharmaceutical Science, Yasuda Women’s University, Hiroshima
Enishi, Tetsuya Division of Rehabilitation, Tokushima University Hospital KAKEN Search Researchers
Sato, Nori Division of Rehabilitation, Tokushima University Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Takahashi, Mitsuhiko Department of Orthopedics, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN Search Researchers
Nakao, Shigetaka Division of Rehabilitation, Tokushima University Hospital
Komatsu, Koji Division of Rehabilitation, Tokushima University Hospital
Yasui, Natsuo Division of Rehabilitation, Tokushima University Hospital|Department of Orthopedics, Institute of Health Biosciences, the University of Tokushima Graduate School Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Keywords
Fourier transform infrared spectroscopy
bone quality
peripheral quantitative computed tomography
three-point bending test
Content Type
Journal Article
Description
We studied the changes of biomaterial and biomechanical properties of the rat
femur during development. Thirty male Wistar rats were allocated to 6 groups : aged 6
weeks (n=5), 9 weeks (n=5), 12 weeks (n=5), 15 weeks (n=5), 24 weeks (n=5), and 36 weeks
(n=5). The mineral to matrix ratio (M/M ratio) of rat femur by Fourier transform infrared
spectroscopy was 0.97 0.10 at the age of 6 weeks, and reached the maximum of 1.52
0.17 at the age of 36 weeks. Total bone mineral density (BMD) by peripheral quantitative
computed tomography of the femoral shaft aged 6 weeks was 479.1 58.7 mg/cm3, and
reached the maximum of 1022.2 42.3 mg/cm3 at the age of 36 weeks. The ultimate load to
failure of the femur of the rat aged 6 weeks by the three-point bending test was 29.6 6.1 N.
At the age of 36 weeks, the ultimate load to failure of the rat femur increased to the maximum
of 283.5 14.7 N. The results showed that the M/M ratio increased with development
as total BMD and bone strength increased. The results suggest that the M/M ratio is one
of the determinants of the biomaterial and biomechanical properties of bone.
Journal Title
The journal of medical investigation : JMI
ISSN
13431420
NCID
AA11166929
Volume
58
Issue
3-4
Start Page
197
End Page
202
Sort Key
197
Published Date
2011-08
Remark
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
departments
University Hospital
Medical Sciences